详情页 - 河北大学附属医院知识库

当前位置：首页 > 详情页

Autophagy flux in bladder cancer: Cell death crosstalk, drug and nanotherapetuics

35| 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Radiotherapy,Affiliated Hospital of Hebei University,Baoding,Hebei 071000,P.R. China [2]Department of Gynecology,Affiliated Hospital of Hebei University,Baoding,Hebei 071000,P.R. China [3]Department of Biomedical Engineering, Erciyes University, Kayseri 38039, Türkiye [4]ERNAM–Nanotechnology Research and Application Center, Erciyes University, Kayseri 38039, Türkiye [5]UNAM−National Nanotechnology Research Center, Bilkent University, Ankara 06800, Türkiye

出处：

DOI：

ISSN：

关键词： Bladder cancer autophagy cell death interactions nanoparticles non-coding RNAs

摘要：

Autophagy, a self-digestion mechanism, has emerged as a promising target in the realm of cancer therapy, particularly in bladder cancer (BCa), a urological malignancy characterized by dysregulated biological processes contributing to its progression. This highly conserved catabolic mechanism exhibits aberrant activation in pathological events, prominently featured in human cancers. The nuanced role of autophagy in cancer has been unveiled as a double-edged sword, capable of functioning as both a pro-survival and pro-death mechanism in a context-dependent manner. In BCa, dysregulation of autophagy intertwines with cell death mechanisms, wherein pro-survival autophagy impedes apoptosis and ferroptosis, while pro-death autophagy diminishes tumor cell survival. The impact of autophagy on BCa progression is multifaceted, influencing metastasis rates and engaging with the epithelial-mesenchymal transition (EMT) mechanism. Pharmacological modulation of autophagy emerges as a viable strategy to impede BCa progression and augment cell death. Notably, the introduction of nanoparticles for targeted autophagy regulation holds promise as an innovative approach in BCa suppression. This review underscores the intricate interplay of autophagy with cell death pathways and its therapeutic implications in the nuanced landscape of bladder cancer.Copyright © 2024. Published by Elsevier B.V.

基金：

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2025]版：

无

最新[2025]版：

大类 | 1 区

医学

小类 | 2 区肿瘤学

JCR分区：

出版当年[2024]版：

无

最新[2023]版：

Q1 ONCOLOGY

影响因子： 9.1 最新[2023版] 8.3 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 9.1 出版前一年[2023版]

第一作者：

第一作者机构： [1]Department of Radiotherapy,Affiliated Hospital of Hebei University,Baoding,Hebei 071000,P.R. China

共同第一作者：

通讯作者：

通讯机构： [3]Department of Biomedical Engineering, Erciyes University, Kayseri 38039, Türkiye [4]ERNAM–Nanotechnology Research and Application Center, Erciyes University, Kayseri 38039, Türkiye [5]UNAM−National Nanotechnology Research Center, Bilkent University, Ankara 06800, Türkiye

推荐引用方式(GB/T 7714)：

APA：

MLA：

相关文献

[1]Autophagy-related lncRNAs and exosomal lncRNAs in colorectal cancer: focusing on lncRNA-targeted strategies [2]肝细胞癌自噬相关长链非编码rna预后模型的建立与分析 [3]精子发生过程中调控性非编码rnas的功能 [4]Long non-coding RNAs and genes contributing to the generation of cancer stem cells in hepatocellular carcinoma identified by RNA sequencing analysis [5]外泌体非编码RNA在胶质瘤发生发展中的作用及其临床应用前景 [6]上皮-间质转化相关长链非编码rna在肝癌中的生物学功能及调控机制 [7]B Doped Zn Single-Atom Nanozyme With Enhanced Oxidase-Like Activity Combined CRISPR/Cas13a System for RNA Sensing [8]Long Noncoding RNA AK021443 Promotes Cell Proliferation and Migration by Regulating Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma Cells [9]MYLK and CALD1 as molecular targets in bladder cancer [10]MiR-1/GOLPH3/Foxo1 Signaling Pathway Regulates Proliferation of Bladder Cancer