机构：[1]Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China首都医科大学附属天坛医院[3]Department of Neurosurgery,Affiliated Hospital of Hebei University,Baoding,China河北大学附属医院重点学科神经外科[4]China National Clinical Research Center for Neurological Diseases, Beijing, China[5]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[6]Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China
Brain arteriovenous malformation (BAVM) is an important risk factor for intracranial hemorrhage, especially in children and young adults. Inflammation has been implicated in BAVM lesion progression. Among various inflammatory components, macrophage is one of the major inflammatory cells present in human ruptured and unruptured BAVM and in the BAVM lesions of animal models. The role of macrophage in BAVM pathogenesis is not fully understood. In this review, we summarize recent studies on macrophages and introduce a non-invasive imaging protocol as a potential tool for detecting macrophage in BAVM and predicting the risk of BAVM rupture.
基金：
This work was supported by grants to Hua Su from the National Institutes of Health (R01 NS027713, R01 HL122774 and R21 NS083788) and from the Michael Ryan Zodda Foundation and UCSF Research Evaluation and Allocation Committee (REAC). Support was also provided by grants from the National Natural Science Foundation of China (81271313) to Yuanli Zhao and Yi Guo, and from the Hebei Provincial Natural Science Foundation of China (H2013201283) to Yi Guo.
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, United States of America[2]Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
通讯作者：
推荐引用方式(GB/T 7714)：
Ma Li,Guo Yi,Zhao Yuan-Li,et al.The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation[J].International Journal Of Hematology Research.2015,1(2):52-56.doi:10.17554/j.issn.2409-3548.2015.01.12.
APA：
Ma Li,Guo Yi,Zhao Yuan-Li&Su Hua.(2015).The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation.International Journal Of Hematology Research,1,(2)
MLA：
Ma Li,et al."The Role of Macrophage in the Pathogenesis of Brain Arteriovenous Malformation".International Journal Of Hematology Research 1..2(2015):52-56
