Macrophage proliferation plays a critical role in kidney injury and repair, but due to their high plasticity and heterogeneity, the origins and subtypes of these proliferating cells remain unclear. This study investigates aldosterone-induced proliferation of renal macrophages, focusing on their origins, subtypes, and regulatory mechanisms using immunofluorescence, flow cytometry, and single-cell sequencing. The findings suggest that both resident and infiltrating macrophages proliferate in response to aldosterone, a significant proportion of which are renal resident macrophages, predominantly of the M1 subtype. The study also identifies the mineralocorticoid receptor/colony stimulation factor-1 (MR/CSF1) pathway as a key regulator of this process. Inhibition of this pathway through antagonists and inhibitors reduces macrophage proliferation and kidney damage, suggesting that targeting MR/CSF1 could be therapeutic against aldosterone-induced renal damage and inflammation.
基金：
National Natural Science Foundation Project of China [82305121, 82174317, 82405271]; Natural Science Fund of Hebei Province [H2023423042]; Postgraduate Innovation Funding Project of the Hebei Province [CXZZBS2024155]
第一作者机构：[1]Hebei Univ Chinese Med, Grad Sch, Shijiazhuang 050200, Peoples R China[2]Hebei Univ Chinese Med, Hebei Key Lab Integrat Med Liver Kidney Patterns, Shijiazhuang 050200, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Hebei Univ Chinese Med, Grad Sch, Shijiazhuang 050200, Peoples R China[2]Hebei Univ Chinese Med, Hebei Key Lab Integrat Med Liver Kidney Patterns, Shijiazhuang 050200, Peoples R China[3]Hebei Univ Chinese Med, Inst Integrat Med, Coll Integrat Med, Shijiazhuang 050200, Peoples R China[*1]Hebei Univ Chinese Med, Coll Integrat Med, 326 Xinshi South Rd, Shijiazhuang 050200, Hebei, Peoples R China
推荐引用方式(GB/T 7714)：
Liu Ziqian,Lv Ruyan,Guo Haixia,et al.Proliferation of renal macrophage via MR/CSF1 pathway induced with aldosterone and inhibited by esaxerenone[J].INTERNATIONAL IMMUNOPHARMACOLOGY.2025,149:doi:10.1016/j.intimp.2025.114208.
APA：
Liu, Ziqian,Lv, Ruyan,Guo, Haixia,Zhang, Boya,Wang, Xuan...&Yang, Fan.(2025).Proliferation of renal macrophage via MR/CSF1 pathway induced with aldosterone and inhibited by esaxerenone.INTERNATIONAL IMMUNOPHARMACOLOGY,149,
MLA：
Liu, Ziqian,et al."Proliferation of renal macrophage via MR/CSF1 pathway induced with aldosterone and inhibited by esaxerenone".INTERNATIONAL IMMUNOPHARMACOLOGY 149.(2025)
