Background: One type of chronic kidney disease is diabetic nephropathy. One of the main causes of end-stage renal disease and chronic kidney disease is diabetic nephropathy. The objective of this study was to assess the effects of treating diabetic nephropathy with conessine extract on male wistar rats with diabetes that had been triggered by streptozotocin. Materials and Methods: Twenty-four rats were split up into four groups. The regular diet was fed to the negative control animals in the first group. After receiving a single intravenous injection of streptozotocin to cause diabetes, the remaining 18 rats were split equally into three groups: the diabetic control group was placed in group 2, the third group received oral treatment with 20 mg/ kg of conessine, and the fourth group received oral treatment with 5 mg/kg of gliclazide. Results: In comparison to the negative control, the rats in the second group had higher glucose and lipid peroxide levels and lower SOD, CAT, GR, GPx, and GSH activity. Diabetes also led to an increase in immunoglobulins, interleukin-6, and carboxymethyl lysine. Potassium and sodium levels were lowered, while kidney function metrics were also raised. Renal tissues also displayed significant histological alterations. Conclusion: Conessine treatments, administered to the diabetic rats in the third improved all altered biochemical and pathological tests that were getting closer to the negative control.