机构：[1]Department of General Surgery,Gastrointestinal Surgery, The First Hospital,China Medical University, Shenyang, China[2]Department of Pathology, First Affiliated Hospital and College of Basic MedicalSciences, China Medical University, Shenyang,China[3]Department of Pathology, Liaoning Cancer Hospital and Institute, Tumor Hospital of China Medical University, Shenyang, China[4]Department of General Surgery,Gastrointestinal Surgery, The Subsidiary Hospital of Hebei University, Baoding, China
ZC3H13 is a canonical CCCH zinc finger protein, which harbors a somatic frame-shift mutation in colorectal cancer (CRC). However, its expression and biological function were still uncertain. In the current study, we found that ZC3H13 was served as a tumor suppressor in CRC cells, which decreased the expression of Snail, Cyclin D1, and Cyclin E1, and increased the expression of Occludin and Zo-1 through inactivating Ras-ERK signaling pathway. Furthermore, reduction of ZC3H13 associated with advanced TNM stage (p = 0.02), positive regional lymph node metastasis (p = 0.01). Taken together, the current study indicated that ZC3H13 may be an upstream regulator of Ras-ERK signaling pathway and suppressed invasion and proliferation of CRC.
基金：
Educational Department of Liaoning Province, China [2012-512]; Shenyang Science and Technology Project of China [F14-158-9-35]
第一作者机构：[1]Department of General Surgery,Gastrointestinal Surgery, The First Hospital,China Medical University, Shenyang, China[4]Department of General Surgery,Gastrointestinal Surgery, The Subsidiary Hospital of Hebei University, Baoding, China
通讯作者：
通讯机构：[1]Department of General Surgery,Gastrointestinal Surgery, The First Hospital,China Medical University, Shenyang, China[*1]Department ofGeneral Surgery, Gastrointestinal Surgery,The First Hospital, China Medical University,110001 Shenyang, Liaoning Province, China.
推荐引用方式(GB/T 7714)：
Zhu Dehua,Zhou Jianping,Zhao Jinbo,et al.ZC3H13 suppresses colorectal cancer proliferation and invasion via inactivating Ras-ERK signaling[J].JOURNAL OF CELLULAR PHYSIOLOGY.2019,234(6):8899-8907.doi:10.1002/jcp.27551.
APA：
Zhu, Dehua,Zhou, Jianping,Zhao, Jinbo,Jiang, Guiyang,Zhang, Xiupeng...&Dong, Ming.(2019).ZC3H13 suppresses colorectal cancer proliferation and invasion via inactivating Ras-ERK signaling.JOURNAL OF CELLULAR PHYSIOLOGY,234,(6)
MLA：
Zhu, Dehua,et al."ZC3H13 suppresses colorectal cancer proliferation and invasion via inactivating Ras-ERK signaling".JOURNAL OF CELLULAR PHYSIOLOGY 234..6(2019):8899-8907
