microRNA (miR)-6852 has been demonstrated to suppress the progression of gastric, colorectal and cervical cancer. The mechanism by which miR-6852 regulates glioma cells is yet to be elucidated. In the present study, reverse transcription-quantitative PCR analysis was used and the results demonstrated that miR-6852 expression was reduced in glioma tissues and cells. Cell counting kit-8 and transwell assay analysis indicated that proliferation, migration and invasion of A172 cells in the miR-6852 mimic group were lower than in the miR-NC group. Compared with the Inh-NC group, A172 cells of the Inh-miR-6852 group exhibited higher proliferation, migration and invasion. Additionally, the results indicated that lymphoid enhancer binding factor 1 (LEF1) was directly inhibited by miR-6852 and LEF1 expression was negatively correlated with miR-6852 expression in glioma tissues. Furthermore, the restoration of LEF1 reversed the effects of the miR-6852 mimics. The present findings suggested that miR-6852 inhibited glioma cells proliferation, migration and invasion by targeting the suppression of LEF1.
第一作者机构：[1]Hebei Univ,Affiliated Hosp,Dept Neurosurg,212 Yuhua East Rd,Baoding 071000,Hebei,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Jialiang,Liu Haipeng,Zheng Kebin,et al.MicroRNA-6852 suppresses glioma A172 cell proliferation and invasion by targeting LEF1[J].EXPERIMENTAL AND THERAPEUTIC MEDICINE.2019,18(3):1877-1883.doi:10.3892/etm.2019.7762.
APA：
Wang, Jialiang,Liu, Haipeng,Zheng, Kebin,Zhang, Shuai&Dong, Wei.(2019).MicroRNA-6852 suppresses glioma A172 cell proliferation and invasion by targeting LEF1.EXPERIMENTAL AND THERAPEUTIC MEDICINE,18,(3)
MLA：
Wang, Jialiang,et al."MicroRNA-6852 suppresses glioma A172 cell proliferation and invasion by targeting LEF1".EXPERIMENTAL AND THERAPEUTIC MEDICINE 18..3(2019):1877-1883
