In the current study, an anticancer nanofibrous membrane was developed for treating endometrial carcinoma. Drug deliv-er y system was produced by incorporation of curcumin into the matrix of electrospun collagen/polycaprolacton scaffolds. Various in vitro experiments were used for characterization of the scaffolds. The produced yarns reduced the viability and migration activity of HEC-1A cells and release the loaded drug in a sustained manner. Furthermore, gene expression studies showed that the anticancer function of the developed delivery system may have been mediated via ERK/c-JUNE signalling pathway. This in vitro experiment suggests potential application of these scaffolds for treating endometrial carcinoma in animal models.