机构：[1]Department of Hepatobiliary Surgery, Hebei International Joint Research Center for Digital Twin Diagnosis and Treatment of Digestive Tract Tumors, Baoding Key Laboratory of Precision Diagnosis and Treatment of Digestive Tract Tumors, Affiliated Hospital of Hebei University, Baoding 071000, China.河北大学附属医院[2]Department of Mechanical Engineering, Beijing University of Technology, Beijing 100124, China.
Friction is the trigger cause for excessive exogenous adhesion, leading to the poor self-repair of the tendon. To address this problem, we developed electrospun dual-functional nanofibers with surface robust superlubricated performance and bioactive agent delivery to regulate healing balance by reducing exogenous adhesion and promoting endogenous healing. Coaxial electrospinning and our previous developed in situ robust nanocoating growth techniques were employed to create the lubricative/repairable core-shell structured nanofibrous membrane (L/R-NM). The L/R-NM shell featured a robust coating of the zwitterionic PMPC polymer for strong hydration lubrication to resist exogenous healing. The core could achieve sustained platelet-rich plasma release to promote endogenous healing. Friction tests and cell experiments confirmed L/R-NM's prominent lubricating properties and antiadhesive performance in vitro. Rat tendon injury model evaluation indicated that L/R-NM effectively promotes high-quality tendon repair by inhibiting friction-induced exogenous adhesion and promoting endogenous healing. Therefore, we believe that L/R-NM will open a unique novel horizon for tendon repair.
基金：
The authors are grateful for the financial support from Beijing
Natural Science Foundation (2244086), Natural Science
Foundation of Hebei Province (H2022201064), Hebei
Provincial Government Subsidized Training Program for
Excellent Talents in Clinical Medicine (ZF2024215,
ZF2025255), Tribology Science Fund of State Key Laboratory
of Tribology in Advanced Equipment (SKLTKF22B01),
Baoding Innovation Capability Enhancement Project
(2494F019).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2026]版：
无
最新[2025]版：
大类|1 区化学
小类|1 区有机化学1 区高分子科学2 区生化与分子生物学
第一作者：
第一作者机构：[1]Department of Hepatobiliary Surgery, Hebei International Joint Research Center for Digital Twin Diagnosis and Treatment of Digestive Tract Tumors, Baoding Key Laboratory of Precision Diagnosis and Treatment of Digestive Tract Tumors, Affiliated Hospital of Hebei University, Baoding 071000, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Hepatobiliary Surgery, Hebei International Joint Research Center for Digital Twin Diagnosis and Treatment of Digestive Tract Tumors, Baoding Key Laboratory of Precision Diagnosis and Treatment of Digestive Tract Tumors, Affiliated Hospital of Hebei University, Baoding 071000, China.[2]Department of Mechanical Engineering, Beijing University of Technology, Beijing 100124, China.
推荐引用方式(GB/T 7714)：
Cao Xin,Li Jinghua,Zhai Weijie,et al.Inhibiting Friction-Induced Exogenous Adhesion via Robust Lubricative Core-Shell Nanofibers for High-Quality Tendon Repair[J].Biomacromolecules.2025,doi:10.1021/acs.biomac.4c01729.
APA：
Cao Xin,Li Jinghua,Zhai Weijie,Zhou Bowen,Lin Hao&Wang Yi.(2025).Inhibiting Friction-Induced Exogenous Adhesion via Robust Lubricative Core-Shell Nanofibers for High-Quality Tendon Repair.Biomacromolecules,,
MLA：
Cao Xin,et al."Inhibiting Friction-Induced Exogenous Adhesion via Robust Lubricative Core-Shell Nanofibers for High-Quality Tendon Repair".Biomacromolecules .(2025)
化学