In this study, doxorubicin (DOX)-loaded long circulating liposomes combined with curcumin (CUR) (DOX-CUR-LCLs) were successfully prepared as a novel formulation for cancer treatment. The particle size and distribution, zeta potential, drug loading capacity, and entrapment efficiency (EE) of the preparation were characterized. The in vitro anti-tumor activities of DOX-CUR-LCLs and DOX-LCLs against A549 cells were then evaluated and compared with that of free DOX. Cytotoxicity evaluation showed that DOX-CUR-LCLs had a significantly higher antitumor activity than other DOX preparations. These results suggest that novel DOX-CUR-LCLs, combination of DOX and CUR administered in long-circulating liposomes, could improve antitumor activity.
基金：
National High Technology Research and Development Program of China (863 Program) [2007 AA021810]; Hebei University [y2005064]
第一作者机构：[1]Hebei Med Univ, Shijiazhuang 050017, Peoples R China[*1]Hebei Med Univ, 361 ZhongShan E Rd, Shijiazhuang 050017, Peoples R China
通讯作者：
通讯机构：[1]Hebei Med Univ, Shijiazhuang 050017, Peoples R China[*1]Hebei Med Univ, 361 ZhongShan E Rd, Shijiazhuang 050017, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Hong,Hu LianDong,Li Chunlei,et al.Increase of therapeutic activity of doxorubicin by long circulating liposomes in combination with curcumin[J].PHARMAZIE.2011,66(11):871-874.doi:10.1691/ph.2011.1057.
APA：
Wang, Hong,Hu, LianDong,Li, Chunlei,Zhang, Jingguo&Zhang, Tao.(2011).Increase of therapeutic activity of doxorubicin by long circulating liposomes in combination with curcumin.PHARMAZIE,66,(11)
MLA：
Wang, Hong,et al."Increase of therapeutic activity of doxorubicin by long circulating liposomes in combination with curcumin".PHARMAZIE 66..11(2011):871-874
