Objective: To investigate the correlation between GAL-3, Klotho, calcium and phosphorus indexes and cardiovascular complications in patients with chronic kidney disease (CKD).Methods: This is a retrospective study. Forty patients with CKD and cardiovascular complications admitted to the Affiliated Hospital of Hebei University from February 20, 2022 to February 20, 2023 were selected as the experimental group, and another 40 patients with CKD without cardiovascular complications were selected as the control group. The differences in serum Ca+2, PO -4, GAL-3 and Klotho levels between the two groups were analyzed, and the correlations between the above indicators levels and creatinine levels were analyzed. The correlation between the above indicators levels and cardiac function classification was analyzed, and analyzed the risk factors of CKD complicated with cardiovascular complications.Results: The levels of Ca+2, PO- and GAL-3 in the experimental group were significantly higher than those in the control 4 group, while the level of Klotho was significantly lower than that in the control group. The levels of Ca+2 and PO- were 4 positively correlated with the level of Creatinine (Cr), while the level of Klotho was negatively correlated with the Cr. The levels of Ca+2 and PO- were positively correlated with cardiac function classification, while the level of Klotho was 4 negatively correlated with cardiac function classification. Logistic regression analysis showed that hypertension, BMI, Cr, Ca+2, PO- and VLDL were risk factors for cardiovascular complications, and Klotho level was a protective factor. 4Conclusion: A positive correlation can be seen between the levels of Ca+2, PO- and cardiac function classification in 4 patients with CKD. Klotho is a protective factor for cardiovascular diseases.