Aim: To evaluate the clinical data and quantitative cerebrospinal fluid for associations with the outcome of cryptococcal meningitis (CM) patients in the hospital. Patients & methods: We retrospectively analyzed a total of 139 CM patients comprising 108 without HIV and 31 with HIV admitted in a Jiang Xi hospital. Results: We found that CM patients with the high fungal burden (>= 10 yeasts/ul) (26.3%) had a worse prognosis than those with the low fungal burden (<10 yeasts/ul). (4.9%) (p = 0.0007 <0.05). Conclusion: In CM patients, a fungal burden of 10 yeasts/ul in the first cerebrospinal fluid test may be used as an indicator of patient prognosis, and we can personalize patients' treatment based on the fungal burden to improve prognosis.
基金：
Chinese Academy of Engineering [19-HN-XZ-06, 2019-XY-33, 2020-XY-61-01]; National Natural Science Foundation of China [31770161]; Science and Technology Commission of Shanghai Municipality [17DZ2272900]; Shanghai Municipal Commission of Health and Family Planning [2017ZZ01024-001]; Major National R&D Projects of the National Health Department [2018ZX10101003]; Shanghai Sailing Program [19YF1448000]
第一作者机构：[1]Second Mil Med Univ, Shanghai Changzheng Hosp, Shanghai Inst Mycol, Shanghai Key Lab Mol Med Mycol, Shanghai 200003, Peoples R China[2]Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Dermatol, Shanghai 200003, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Second Mil Med Univ, Shanghai Changzheng Hosp, Shanghai Inst Mycol, Shanghai Key Lab Mol Med Mycol, Shanghai 200003, Peoples R China[2]Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Dermatol, Shanghai 200003, Peoples R China[6]Jiangxi Chest Hosp, Dept Neurol, Nanchang 330000, Jiangxi, Peoples R China[7]Jiangxi Prov Peoples Hosp, Dept Neurol, Nanchang 330000, Jiangxi, Peoples R China
推荐引用方式(GB/T 7714)：
Zhang Keming,Li Hang,Zhang Lei,et al.Cerebrospinal fluid microscopy as an index for predicting the prognosis of cryptococcal meningitis patients with and without HIV[J].FUTURE MICROBIOLOGY.2020,15(17):1645-1652.doi:10.2217/fmb-2020-0086.
APA：
Zhang, Keming,Li, Hang,Zhang, Lei,Liao, Wanqing,Ling, Liyan...&Zhang, Qilong.(2020).Cerebrospinal fluid microscopy as an index for predicting the prognosis of cryptococcal meningitis patients with and without HIV.FUTURE MICROBIOLOGY,15,(17)
MLA：
Zhang, Keming,et al."Cerebrospinal fluid microscopy as an index for predicting the prognosis of cryptococcal meningitis patients with and without HIV".FUTURE MICROBIOLOGY 15..17(2020):1645-1652
