BackgroundThe clinical profiles and outcomes of cryptococcal meningitis have been shown to vary depending on the underlying condition. The aim of this study was to investigate clinical characteristics and outcomes in patients with and without type II diabetes mellitus.MethodsA retrospective study was performed. Clinical data of HIV-negative cryptococcal meningitis patients with type II diabetes mellitus (n=26) and without type II diabetes mellitus (n=52) referring to the Jiangxi Chest Hospital between January 2012 to December 2018 were analyzed. The data were analyzed using chi square, none-parametric tests, and logistic regression. P-values <0.05 were considered significant.ResultsIn this study, cryptococcal meningitis patients suffering from type II diabetes mellitus had a higher mortality (23.08% vs. 7.69%; P=0.055), and required longer hospitalization (59.58 vs. 42.88days; P=0.132). Moreover, cerebrospinal fluid examinations revealed that cryptococcal meningitis patients with type II diabetes mellitus had higher opening pressure (271.54 vs. 234.23 mmH(2)O; P=0.125).The results of multivariate regression analysis revealed that cryptococcal meningitis patients with type II diabetes were more often presented with visual disorders (28.54% vs. 11.54%; [95% CI 0.056-0.705]; p=0.012), and had higher cerebrospinal fluid protein levels (1027.62594.16 vs. 705.72 +/- 373.88mg/l; [95% CI 1.000-1.002]; p=0.016). Among patients with type II diabetes mellitus, nausea and vomiting was more frequent at the initial visit in those died (100% vs. 50%; p=0.027), and 66% of died type II diabetes mellitus patients were poorly controlled blood glucose level, compared with 30% in survival type II diabetes mellitus patients. Conclusion This study suggests that cryptococcal meningitis patients with type II diabetes mellitus differ significantly from cryptococcal meningitis patients without type II diabetes mellitus with respect to clinical symptoms such as visual disorders and cerebrospinal fluid examination. The presence of nausea and vomiting among type II diabetes mellitus patients could have implication in mortality.
基金：
Major National R&D Projects of the National Health Department [2018ZX10101003]; National Natural Science Foundation of China [82072257]; Shanghai Science and Technology Committee [17DZ2272900]; Shanghai Municipal Commission of Health and Family Planning [2017ZZ01024-001]; Shanghai Sailing Program [19YF1448000]; Chinese Academy of Engineering [2019-XY-33, 19-HNXZ-06, 2020-XY-61-01]
第一作者机构：[1]Second Mil Med Univ, Shanghai Changzheng Hosp, Shanghai Key Lab Mol Med Mycol, Shanghai 200003, Peoples R China[2]Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Dermatol, Shanghai 200003, Peoples R China
通讯作者：
通讯机构：[1]Second Mil Med Univ, Shanghai Changzheng Hosp, Shanghai Key Lab Mol Med Mycol, Shanghai 200003, Peoples R China[2]Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Dermatol, Shanghai 200003, Peoples R China[8]Jiangxi Chest Hosp, Dept Neurol, Nanchang 330000, Jiangxi, Peoples R China[9]Jiangxi Prov peoples Hosp, Dept Neurol, Nanchang 330006, Jiangxi, Peoples R China
推荐引用方式(GB/T 7714)：
Li Hang,Li Xiaojing,Zhang Lei,et al.The clinical profiles and outcomes of HIV-negative cryptococcal meningitis patients in type II diabetes mellitus[J].BMC INFECTIOUS DISEASES.2021,21(1):doi:10.1186/s12879-021-05867-5.
APA：
Li, Hang,Li, Xiaojing,Zhang, Lei,Fang, Wenjie,Zhang, Keming...&Zhang, Qilong.(2021).The clinical profiles and outcomes of HIV-negative cryptococcal meningitis patients in type II diabetes mellitus.BMC INFECTIOUS DISEASES,21,(1)
MLA：
Li, Hang,et al."The clinical profiles and outcomes of HIV-negative cryptococcal meningitis patients in type II diabetes mellitus".BMC INFECTIOUS DISEASES 21..1(2021)
