Spermatogenesis is a highly complex process involving dynamic erasure and establishment of epigenetic modifications. Abnormal epigenetic marks have been shown to result in altered spermatogenesis and even cause male infertility. Assisted reproductive technology, with directly dealing and selecting the morphology qualified sperm, can be applied to treat male infertility, which may carry significant risks of passing on epigenetic defects to next generations. Selecting epigenetic qualified sperm is an effective way to reduce the risk of inheritance between generations. In this review, we mainly assess the risks of sperm with epigenetic defects and their effects on offspring health, to provide some basic information for the quality control of sperm via detecting their epigenetic biomarkers, which is essential for successfully treating male infertility via assisted reproductive technology.
基金：
Hebei Province Natural Science Foundation of China [H2018201218]
第一作者机构：[1]Hebei Univ, Hlth Sci Ctr, Baoding, Peoples R China[2]Hebei Univ, Inst Reprod Med, Baoding, Peoples R China[3]Hebei Univ, Ctr Reprod Med, Affiliated Hosp, Baoding 071002, Peoples R China
通讯作者：
通讯机构：[4]Chinese Acad Sci, State Key Lab Stem Cell & Reprod Biol, Inst Zool, Beichen West Rd, Beijing 100101, Peoples R China[5]Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Ge Shaoqin,Zhao Penghui,Liu Xuanchen,et al.Necessity to Evaluate Epigenetic Quality of the Sperm for Assisted Reproductive Technology[J].REPRODUCTIVE SCIENCES.2019,26(3):315-322.doi:10.1177/1933719118808907.
APA：
Ge, Shaoqin,Zhao, Penghui,Liu, Xuanchen,Zhao, Zhenghui&Liu, Meiyun.(2019).Necessity to Evaluate Epigenetic Quality of the Sperm for Assisted Reproductive Technology.REPRODUCTIVE SCIENCES,26,(3)
MLA：
Ge, Shaoqin,et al."Necessity to Evaluate Epigenetic Quality of the Sperm for Assisted Reproductive Technology".REPRODUCTIVE SCIENCES 26..3(2019):315-322
