Mapping epigenetic modifications and identifying their roles in the regulation of spermatogenesis and embryogenesis are essential for gaining fundamental medical understandings and for clinical applications. More and more evidence has shown that specific epigenetic modifications are established during spermatogenesis, which will be transferred into oocyte via fertilisation, and play an important role in the early embryo development. Defects in epigenetic patterns may increase the risk of abnormal spermatogenesis, fertilisation failure, early embryogenesis abnormality and several other complications during pregnancy. This review mainly discusses the relationship between altered epigenetic profiles and reproductive diseases, highlighting how epigenetic defects affect the quality of sperm and embryo.
基金：
National Natural Science Foundation of China [31472055]; Hebei Province Natural Science Foundation of China [H2013201259]
第一作者机构：[1]Hebei Univ, Hlth Sci Ctr, Baoding, Peoples R China[2]Hebei Univ, Inst Reprod Med, Baoding, Peoples R China[3]Hebei Univ, Affiliated Hosp, Ctr Reprod Med, Baoding, Peoples R China[4]Hebei Res Inst Family Planning, Shijiazhuang, Hebei, Peoples R China
通讯作者：
通讯机构：[6]Chinese Acad Sci, Inst Zool, State Key Lab Stem Cell & Reprod Biol, Beijing, Peoples R China[7]Univ Chinese Acad Sci, Beijing, Peoples R China
推荐引用方式(GB/T 7714)：
Ge Shao-Qin,Lin Sheng-Li,Zhao Zheng-Hui,et al.Epigenetic dynamics and interplay during spermatogenesis and embryogenesis: implications for male fertility and offspring health[J].ONCOTARGET.2017,8(32):53804-53818.doi:10.18632/oncotarget.17479.
APA：
Ge, Shao-Qin,Lin, Sheng-Li,Zhao, Zheng-Hui&Sun, Qing-Yuan.(2017).Epigenetic dynamics and interplay during spermatogenesis and embryogenesis: implications for male fertility and offspring health.ONCOTARGET,8,(32)
MLA：
Ge, Shao-Qin,et al."Epigenetic dynamics and interplay during spermatogenesis and embryogenesis: implications for male fertility and offspring health".ONCOTARGET 8..32(2017):53804-53818
