Curcumin is a potential natural anticancer drug with low oral bioavailability because of poor water solubility. The aqueous solubility of curcumin is enhanced by means of modification with the carbohydrate units. Polymerization of the curcumin-containing monomer with carbohydrate-containing monomer gives the water-soluble glycopolymer bearing curcumin pendant residues. The obtained copolymers (P1 and P2) having desirable water solubility were well-characterized by infrared spectroscopy (IR), nuclear magnetic resonance (NMR), gel permeation chromatography (GPC), UV-Vis absorption spectroscopy, and photoluminescence spectroscopy. The copolymer P2 with a molar ratio of 1:6 (curcumin/carbohydrate) calculated from the proton NMR results exhibits a similar anticancer activity compared to original curcumin, which may serve as a potential chemotherapeutic agent in the field of anticancer medicine.
基金：
National Natural Science Foundation of China [21274037, 21474026]; Natural Science Foundation of Hebei Province [2013201174]; Post-graduate's Innovation Fund Project of Hebei Province [S2016001]
第一作者机构：[1]Hebei Univ, Coll Chem & Environm Sci, Baoding, Peoples R China[2]Hebei Univ,Affiliated Hosp,Dept Nephrol,Baoding,Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhang Haisong,Yu Meng,Zhang Hailei,et al.Synthesis, characterization and fluorescent properties of water-soluble glycopolymer bearing curcumin pendant residues[J].BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY.2016,80(8):1451-1458.doi:10.1080/09168451.2016.1171696.
APA：
Zhang, Haisong,Yu, Meng,Zhang, Hailei,Bai, Libin,Wu, Yonggang...&Ba, Xinwu.(2016).Synthesis, characterization and fluorescent properties of water-soluble glycopolymer bearing curcumin pendant residues.BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,80,(8)
MLA：
Zhang, Haisong,et al."Synthesis, characterization and fluorescent properties of water-soluble glycopolymer bearing curcumin pendant residues".BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 80..8(2016):1451-1458
