This study was designed to scrutinize the clinical effectiveness of intrathecal injection of medicine along with constant lumbar cistern drainage on intracranial infection subsequent to intracranial tumor operation. Sixty two patients with intracranial infection after intracranial tumor surgery were selected as the objects of study divided into combined treatment group (n=31) and the control group (n=31) according to the time of admission. Patients in the combined treatment group were treated with intrathecal injection of medicine combined with group's continuous lumbar cistern drainage while patients in the control group were just treated with intravenous antibiotic therapy followed by comparison in the clinical efficacy, infection control, the level of inflammatory factor like crp, IL-4 and incidence of complication in the two groups were compared respectively. The total effectiveness rate was 96.77% in the combined treatment group and 80.65% in the control group indicating statistical significant difference (p<0.05). The average time of infection control in the combined treatment group and the control group was 9.05 +/- 2.08 and 17.07 +/- 3.34 days respectively. After treatment, the restoration effect of serum crp and IL-4 in the combined treatment group was better (p<0.05). The complication incidence of patients in the combined treatment group was 3.23% while it was 16.13% in the control group. Therefore, the difference between the two groups was statistically significant (p<0.05).This advanced combination therapy proved to be effective as the total clinical efficacy was relatively high. Moreover, the combination therapy also shortened the time of infection control with lesser complication rate and reduce inflammatory factor.