Clinical practice and outcome of radiotherapy for advanced esophageal squamous cell carcinoma between 2002 and 2018 in China: the multi-center 3JECROG Survey.
机构:[1]Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.[2]Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.河北医科大学第四医院[3]Department of Radiation Oncology, Fujian Cancer Hospital/Fujian Medical University Cancer Hospital, Fuzhou, China.[4]Department of Radiation Oncology, Tianjin Medical University Cancer Institute and Hospital/National Clinical Research Center for Cancer, Tianjin, China.[5]Department of Radiation Oncology, Anyang Cancer Hospital, Anyang, China.[6]Department of Radiation Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.江苏省人民医院[7]Department of Oncology, Tengzhou Central People's Hospital, Tengzhou, China.[8]Department of Radiation Oncology, Beijing Hospital, National Center of Gerontology, Beijing, China.[9]Department of Radiation Oncology, Affiliated Hospital of Hebei University, Baoding, China.河北大学附属医院[10]Department of Radiation Oncology, PLA Army General Hospital, Beijing, China.[11]Department of Radiation Oncology, Cancer Hospital Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen, China.深圳市康宁医院深圳医学信息中心中国医学科学院肿瘤医院深圳医院
To determine the survival and prognostic factors of esophageal squamous cell carcinoma (ESCC) patients undergoing radical (chemo)radiotherapy in the era of three-dimensional conformal radiotherapy (3DCRT) and intensity modulated radiotherapy (IMRT) in China.
The Jing-Jin-Ji Esophageal and Esophagogastric Cancer Radiotherapy Oncology Group (3JECROG) conducted the first nationwide survey of nine institutions. Detailed information was accumulated on 5185 patients with ESCC who received definitive 3DCRT/IMRT between 2002 and 2018. Relevant prognostic factors were evaluated to assess their influence on overall and progression-free survivals.
After a median follow-up time of 47.0 (0.9-157.4) months, the 1-year, 2-year, 3-year and 5-year overall survival rates of the whole group were 69.8%, 46.6%, 37.9% and 30.1%. The 1-year, 2-year, 3-year, and 5-year progression-free survival rates were 54.1%, 36.6%, 30.5% and 24.9%. Multivariate analysis demonstrated that sex, clinical stage, treatment modality and radiation dose were prognostic factors for OS. The survival of patients who received concurrent chemoradiotherapy (CCRT) was better than that of patients who received radiotherapy alone or sequential chemoradiotherapy. Patients receiving adjuvant chemotherapy after CCRT had a better OS than patients receiving CCRT alone. Patients receiving higher radiation dose had a better OS than those patients receiving low-dose radiotherapy.
The survival of ESCC patients undergoing radical (chemo)radiotherapy was relatively satisfactory in the era of 3DCRTand IMRT. As the largest-scale multicenter research on esophageal cancer radiotherapy conducted in China, this study establishes national benchmarks and helps to provide references for subsequent related researches.
基金:
This work was supported by the Beijing Hope Run Special Fund of
Cancer Foundation of China (LC2016L04) and National Key Projects of
Research and Development of China (2016YFC0904600)
第一作者机构:[1]Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
共同第一作者:
通讯作者:
通讯机构:[1]Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.[2]Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.[*1]Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China[*2]Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
推荐引用方式(GB/T 7714):
Li Chen,Wang Xin,Wang Lan,et al.Clinical practice and outcome of radiotherapy for advanced esophageal squamous cell carcinoma between 2002 and 2018 in China: the multi-center 3JECROG Survey.[J].ACTA ONCOLOGICA.2021,60(5):627-634.doi:10.1080/0284186X.2021.1902564.
APA:
Li Chen,Wang Xin,Wang Lan,Chen Junqiang,Zhang Wencheng...&Xiao Zefen.(2021).Clinical practice and outcome of radiotherapy for advanced esophageal squamous cell carcinoma between 2002 and 2018 in China: the multi-center 3JECROG Survey..ACTA ONCOLOGICA,60,(5)
MLA:
Li Chen,et al."Clinical practice and outcome of radiotherapy for advanced esophageal squamous cell carcinoma between 2002 and 2018 in China: the multi-center 3JECROG Survey.".ACTA ONCOLOGICA 60..5(2021):627-634