Rationale: At present, there is no uniform consensus on the treatment of recurrent glioblastoma, especially the re-irradiation dose and temozolomide (TMZ) dose. The literature on the treatment of recurrent glioblastoma (GBM) by conventionally fractionated stereotactic radiotherapy (CFRT) is even rarer. Patient concerns: A 44-year-old woman was admitted to our hospital for residual tumor after reoperation. Diagnoses: Postoperative pathological diagnosis was GBM, WHO grade IV. The brain magnetic resonance imaging re-examination showed abnormal enhancement around the local operative region after resection of the left frontal lobe tumor, and there was presence of residual tumor. Interventions: The patient was treated with reoperation followed by re-irradiation plus dose-dense TMZ to achieve complete remission. Outcomes: Complete remission was observed at the end of radiotherapy and at the 1 month follow-up after radiotherapy. Lessons: This study suggests that CFRT plus dose-dense TMZ might be a feasible option for the treatment in relapsed malignant glioma patients with good general condition.