Background: The formation of hepatic hemangiomas (HH) is associated with VEGF and IL-7 that alter conduit arteries and small arterioles. To our knowledge, there are no studies to investigate the effects of HH on the hemodynamics in conduit arteries. The aim of the study is to perform morphometric and hemodynamic analysis in abdominal conduit arteries and bifurcations of HH patients and controls. Methods: Based on morphometry reconstructed from CT images, geometrical models were meshed with prismatic elements for the near wall region and tetrahedral and hexahedral elements for the core region. Simulations were performed for computation of the non-Newtonian blood flow using the Carreau-Yasuda model, based on which multiple hemodynamic parameters were determined. Results: There was an increase of the lumen size, diameter ratio, and curvature in the abdominal arterial tree of HH patients as compared with controls. This significantly increased the surface area ratio of low time-averaged wall shear stress (i.e., SAR-TAWSS [Formula: see text] 100%) (24.1 ± 7.9 vs. 5 ± 6%, 11.6 ± 12.8 vs. < 0.1%, and 44.5 ± 9.2 vs. 21 ± 24% at hepatic bifurcations, common hepatic arteries, and abdominal aortas, respectively, between HH and control patients). Conclusions: Morphometric changes caused by HH significantly deteriorated the hemodynamic environment in abdominal conduit arteries and bifurcations, which could be an important risk factor for the incidence and progression of vascular diseases.
基金：
the National Natural
Science Foundation of China Grant 11672006 (YH) and
11732001 (WT), the Shenzhen Science and Technology R&D
Grant JCYJ20160427170536358 (YH), and the Hebei University
Medical Construction Grant 2015A1002 (YH).
第一作者机构：[1]Department of Radiology, Affiliated Hospital of Hebei University, Hebei University, Baoding, China,
共同第一作者：
通讯作者：
通讯机构：[2]Department ofMechanics and Engineering Science, College of Engineering, Peking University, Beijing, China,[3]College of Medicine, HebeiUniversity, Baoding, China,[4]PKU-HKUST Shenzhen-Hongkong Institution, Shenzhen, China,
推荐引用方式(GB/T 7714)：
Yin Xiaoping,Huang Xu,Li Qiao,et al.Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations.[J].FRONTIERS IN PHYSIOLOGY.2018,9:334.doi:10.3389/fphys.2018.00334.
APA：
Yin Xiaoping,Huang Xu,Li Qiao,Li Li,Niu Pei...&Huo Yunlong.(2018).Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations..FRONTIERS IN PHYSIOLOGY,9,
MLA：
Yin Xiaoping,et al."Hepatic Hemangiomas Alter Morphometry and Impair Hemodynamics of the Abdominal Aorta and Primary Branches From Computer Simulations.".FRONTIERS IN PHYSIOLOGY 9.(2018):334
