机构：[1]Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing,China[2]State Key Laboratory for Turbulence and Complex Systems, College of Engineering, PekingUniversity, Beijing, China[3]State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, NationalCenter for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union MedicalCollege, Beijing, China[4]Department of Cardiology, Affiliated hospital of Hebei University, Hebei University,Baoding, China河北大学附属医院[5]National Heart Center Singapore, Singapore, Singapore[6]Duke-NUS Graduate MedicalSchool Singapore, Singapore, Singapore[7]California Medical Innovations Institute, San Diego, California,United States of America[8]School of Biomedical Engineering, Capital Medical University, Beijing, China
Serial segmental narrowing frequently occurs in humans, which alters coronary hemodynamics and further affects atherosclerotic progression and plaque formation. The objective of this study was to understand the distribution of hemodynamic parameters in the epicardial left main coronary arterial (LMCA) tree with serial stenoses reconstructed from patient computer tomography angiography (CTA) images. A finite volume method was used in conjunction with the inlet pressure wave and outlet flow resistance. The time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI) were determined from the flow field. A stenosis at a mother vessel mainly deteriorated the hemodynamics near the bifurcation while a stenosis at a daughter vessel affected the remote downstream bifurcation. In comparison with a single stenosis, serial stenoses increased the peak pressure gradient along the main trunk of the epicardial left anterior descending arterial tree by > 50%. An increased distance between serial stenoses further increased the peak pressure gradient. These findings have important implications on the diagnosis and treatment of serial coronary stenoses.
基金：
Natural Science Foundation of China [11372010]; China MOST Grant [2014DFG32740]; Singapore BMRC Grant [1215c013]; Postdoctoral Science Foundation of China [2014M550009]; California Medical Innovations Institute
第一作者机构：[1]Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing,China[2]State Key Laboratory for Turbulence and Complex Systems, College of Engineering, PekingUniversity, Beijing, China[8]School of Biomedical Engineering, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Mechanics and Engineering Science, College of Engineering, Peking University, Beijing,China[2]State Key Laboratory for Turbulence and Complex Systems, College of Engineering, PekingUniversity, Beijing, China
推荐引用方式(GB/T 7714)：
Xi Chen,Yang Gao,Bin Lu,et al.Hemodynamics in Coronary Arterial Tree of Serial Stenoses[J].PLOS ONE.2016,11(9):doi:10.1371/journal.pone.0163715.
APA：
Xi Chen,Yang Gao,Bin Lu,Xinwei Jia,Liang Zhong...&Yunlong Huo.(2016).Hemodynamics in Coronary Arterial Tree of Serial Stenoses.PLOS ONE,11,(9)
MLA：
Xi Chen,et al."Hemodynamics in Coronary Arterial Tree of Serial Stenoses".PLOS ONE 11..9(2016)
