机构：[1]The Affiliated Shenzhen Luohu Hospital of Anhui Universityof Science and Technology, Shenzhen, China深圳市罗湖区人民医院深圳医学信息中心[2]Urology Institute of Shenzhen University, The ThirdAffiliated Hospital of Shenzhen University, Shenzhen, China[3]Department of Urology, Guangdong Key Laboratoryof Urology, The First Affiliated Hospital of GuangzhouMedical University, Shenzhen, China深圳市康宁医院深圳医学信息中心[4]Department of Urology, National Cancer Center/NationalClinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking UnionMedical College, Beijing, China[5]Affiliated Hospital of Hebei University, Baoding, Hebei,China河北大学附属医院
Bladder cancer is one of the most aggressive urothelial tumors. Previous studies have suggested that epithelial-mesenchymal transition (EMT) contributes to bladder cancer progression. However, the regulatory network of EMT in bladder cancer remains elusive. In this study, we found Yin Yang 1 (YY1) is a critical regulator of EMT in bladder cancer. First, we showed that YY1 was upregulated in bladder cancer tissues than that in adjacent normal tissues. Then, we proved that YY1 promoted EMT of bladder cancer cells. Further experiments indicated that YY1 affected the EMT of bladder cancer through transforming growth factor-β (TGFβ) signaling pathway. Taken together, our study identifies YY1 as a key EMT driver in bladder cancer, suggesting it as a potential therapeutic target.
基金：
the National Natural Science
Foundation of China (81672533, 81702519, 81802741), National Postdoctoral
Program for Innovative Talents (BX20180309), Shenzhen Key
lab (ZDSYS20190902092857146), and the Special Funds for Strategic
Emerging Industries Development in Shenzhen (20180309163446298).
The Shenzhen Basic Research Project (JCYJ20170412155305340,
JCYJ20170818110900404).
第一作者机构：[1]The Affiliated Shenzhen Luohu Hospital of Anhui Universityof Science and Technology, Shenzhen, China[2]Urology Institute of Shenzhen University, The ThirdAffiliated Hospital of Shenzhen University, Shenzhen, China
共同第一作者：
通讯作者：
通讯机构：[1]The Affiliated Shenzhen Luohu Hospital of Anhui Universityof Science and Technology, Shenzhen, China[2]Urology Institute of Shenzhen University, The ThirdAffiliated Hospital of Shenzhen University, Shenzhen, China[3]Department of Urology, Guangdong Key Laboratoryof Urology, The First Affiliated Hospital of GuangzhouMedical University, Shenzhen, China
推荐引用方式(GB/T 7714)：
Wuchao Xia,Yuqing Li,Zhangsong Wu,et al.Transcription factor YY1 mediates epithelial-mesenchymal transition through the TGFβ signaling pathway in bladder cancer.[J].MEDICAL ONCOLOGY.2020,37(10):93.doi:10.1007/s12032-020-01414-5.
APA：
Wuchao Xia,Yuqing Li,Zhangsong Wu,Yongqiang Wang,Nianzeng Xing...&Song Wu.(2020).Transcription factor YY1 mediates epithelial-mesenchymal transition through the TGFβ signaling pathway in bladder cancer..MEDICAL ONCOLOGY,37,(10)
MLA：
Wuchao Xia,et al."Transcription factor YY1 mediates epithelial-mesenchymal transition through the TGFβ signaling pathway in bladder cancer.".MEDICAL ONCOLOGY 37..10(2020):93
