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Green synthesis of a urea-melamine-hexamethylenetetramine resin for efficient extraction and determination of berberine hydrochloride in Pudilan antiphlogistic oral liquid

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机构： [1]Xingtai Medical College, Xingtai 054000, China. [2]Department of Pharmacy, Affiliated Hospital of Hebei University, Baoding 071002, China. [3]Key Laboratory of Molecular Pathology and Early Diagnosis of Tumor in Hebei Province, Department of Pathology, Baoding NO.1 Central Hospital, Baoding 071000, China. [4]Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Pharmaceutical Sciences, College of Chemistry and Materials Science, Hebei University, Baoding 071002, China.

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关键词： Solid-phase extraction Urea-melamine-hexamethylenetetramine resin Berberine hydrochloride Liquid chromatography Pudilan antiphlogistic oral liquid

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A urea-melamine-hexamethylenetetramine resin (UMHR) was synthesized using water as the reaction medium, with hexamethylenetetramine serving as an environmentally friendly crosslinking agent in place of traditional formaldehyde. The resin was optimized as an efficient solid-phase extraction (SPE) adsorbent through optimization of synthetic parameters. A precise detection method for berberine hydrochloride in Pudilan antiphlogistic oral liquid was established by optimizing extraction parameters. The method exhibited excellent linearity, with a correlation coefficient (r ≥ 0.9998) over a concentration range of 0.40-100.0 μg/mL. The limits of detection (LOD) and quantitation (LOQ) were 0.094 μg/mL and 0.314 μg/ mL, respectively. Recoveries ranged from 87.9 % to 97.3 %, with relative standard deviations (RSDs) below 3.2 %. This study presents a novel and environmentally friendly analytical approach for the quality control of traditional Chinese medicine preparations.Copyright © 2025. Published by Elsevier B.V.

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大类 | 2 区

化学

小类 | 1 区生化研究方法 2 区分析化学

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第一作者机构： [1]Xingtai Medical College, Xingtai 054000, China.

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