机构：[1]Hebei Univ Chinese Med, Hebei Prov Hosp Chinese Med, Dept Radiotherapy, Shijiazhuang, Peoples R China[2]China Acad Chinese Med Sci, Guanganmen Hosp, Dept Gastroenterol, Beijing, Peoples R China[3]Key Lab Integrated Chinese & Western Med Gastroent, Shijiazhuang, Peoples R China
Background An updated meta-analysis was conducted to evaluate the efficacy of radiotherapy in rectal cancer patients treated with total mesorectal excision (TME) or other types of surgery (non-TME-only). Methods The PubMed, Cochrane Library, and CNKI databases were searched. Data on overall survival (OS) were extracted. Results Hazard ratios (HRs) for OS associated with preoperative radiotherapy, preoperative long-course concurrent chemoradiotherapy (LCCRT), preoperative radiotherapy alone, and postoperative radiotherapy in patients treated with TME were 1.02 [95% CI: 0.92-1.14, P = 0.65], 1.04 [95% CI: 0.93-1.16, P = 0.47], 0.87 [95% CI: 0.61-1.25, P = 0.46], and 1.18 [95% CI: 0.91-1.52, P = 0.20], respectively. HRs for OS associated with preoperative radiotherapy, preoperative LCCRT, preoperative radiotherapy alone, preoperative long-course RT (LCRT), and preoperative short-course radiotherapy (SCRT) in patients treated with non-TME-only surgery were 0.85 [95% CI: 0.79-0.90, P < 0.00001], 0.77 [95% CI: 0.63-0.94, P = 0.009], 0.86 [95% CI: 0.80-0.92, P < 0.0001], 0.83 [95% CI: 0.73-0.95, P = 0.005], and 0.84 [95% CI: 0.77-0.91, P= <0.0001], respectively. The HR for postoperative radiotherapy in patients treated with non-TME-only surgery was 1.08 [95% CI: 0.84-1.39, P = 0.57]. Conclusion Preoperative radiotherapy, regardless of the regimen, improves the OS in patients treated with non-TME-only surgery, but not in those treated with TME. Postoperative radiotherapy does not improve OS.
基金：
Hebei Administration of Traditional Chinese Medicine [2023020]
第一作者机构：[1]Hebei Univ Chinese Med, Hebei Prov Hosp Chinese Med, Dept Radiotherapy, Shijiazhuang, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Hebei Univ Chinese Med, Hebei Prov Hosp Chinese Med, Dept Radiotherapy, Shijiazhuang, Peoples R China[3]Key Lab Integrated Chinese & Western Med Gastroent, Shijiazhuang, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Wenshu,Zhao Runyuan,Liang Xi,et al.Efficacies of radiotherapy in rectal cancer patients treated with total mesorectal excision or other types of surgery: an updated meta-analysis[J].ONCOLOGY REVIEWS.2025,19:doi:10.3389/or.2025.1567818.
APA：
Wang, Wenshu,Zhao, Runyuan,Liang, Xi,Liu, Manjun,Bai, Haiyan...&He, Jianming.(2025).Efficacies of radiotherapy in rectal cancer patients treated with total mesorectal excision or other types of surgery: an updated meta-analysis.ONCOLOGY REVIEWS,19,
MLA：
Wang, Wenshu,et al."Efficacies of radiotherapy in rectal cancer patients treated with total mesorectal excision or other types of surgery: an updated meta-analysis".ONCOLOGY REVIEWS 19.(2025)
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