This case report presents the surgical management of a complex abdominal sarcoma in a 33-year-old female patient, emphasizing the pivotal role of advanced imaging and three-dimensional (3D) printing technology in optimizing surgical outcomes. The study aimed to explore the clinical value of integrating computed tomography, magnetic resonance imaging, and patient-specific 3D-printed models for preoperative planning, intraoperative navigation, and postoperative evaluation. A multidisciplinary team utilized Mimics23 software to generate a detailed 3D reconstruction of the tumor and its intricate anatomical relationships with the ileocecal region, appendix, and colon. This model guided the precise resection of a 15 × 10 × 10 cm high-grade sarcoma, minimizing damage to adjacent critical structures. The technology-enhanced approach resulted in complete tumor excision with clear margins, and postoperative no complications. This case underscores the potential of 3D visualization and printing to address the challenges of complex abdominal sarcomas, offering a paradigm for personalized surgical strategies in oncology.Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2025.