Objective: Colorectal cancer (CRC) screening is crucial for early detection and prevention. However, the willingness of first-degree relatives of CRC patients to undergo colonoscopy often remains low, impacting early diagnosis and treatment outcomes. Methods: This article reviewed the relevant concepts, research status, evaluation methods, influencing factors and intervention measures of first-degree relatives of patients with colorectal cancer. Results: Through the review, it is found that there is still a large gap in the research on the development of assessment tools and intervention programs. Existing intervention programs often fail to address the unique demographic, cognitive, psychological, family dynamic, and social barriers faced by this population. Future research should prioritize the development of specific assessment tools that can accurately measure the willingness of first-degree relatives to undergo colonoscopy, taking into account cultural nuances and contextual factors. By addressing psychological and social factors, researchers can develop more targeted and effective programs that enhance understanding and motivation for colonoscopy screening. Conclusion: This study provides references for domestic research on the willingness of first-degree relatives for colonoscopy, provide new ideas for formulating intervention methods more suitable for first-degree relatives for colonoscopy, and promote their willingness to perform colonoscopy.