Hyperuricemia, a disorder of purine metabolism associated with cardiovascular disease, gout, and kidney disease, can be alleviated by food-derived peptides. However, the precise mechanisms remain unclear, hindering their development. This study reviews uric acid-lowering peptides from various sources, focusing on two pathways: inhibiting uric acid production and promoting excretion. Low-molecular-weight peptides (<1000 Da) exhibited superior uric acid-lowering effects. We further explored the relationships between amino acid composition and their target interactions. Peptides rich in cyclic amino acids (tryptophan, phenylalanine, and histidine) and containing small amounts of linear amino acids (leucine, cysteine, and glycine) demonstrated significant potential for lowering uric acid. These findings provide theoretical support for developing novel functional foods for the management of hyperuricemia.
基金：
This work was supported by the Natural Science Foundation of Hebei Province (No.
H2021206139), the National Key Research and Development Program of China (No. 2021YFD2100402),
and the 2024 Graduate Research Capacity Enhancement Program Project Grant.
第一作者机构：[1]Beijing Technol & Business Univ, Key Lab Geriatr Nutr & Hlth, Minist Educ, Beijing 100048, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Han Yu,Liu Wanlu,Li Kexin,et al.Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects[J].FOODS.2025,14(1):doi:10.3390/foods14010058.
APA：
Han, Yu,Liu, Wanlu,Li, Kexin,Zhang, Mingzhen,Liu, Xinqi...&Li, He.(2025).Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects.FOODS,14,(1)
MLA：
Han, Yu,et al."Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects".FOODS 14..1(2025)
