Based on reports regarding the effect of propofol, in different concentrations on the differentiation of normal spleen dendritic cells to immune cells, this study aimed to clarify the anti-inflammatory and immunomodulatory effect of propofol. Spleen dendritic cells were selected as research material, isolated from male mice. Propofol in different concentrations was cultured with the dendritic cells stimulated with lipopolysaccharide (LPS). The expression of spleen dentritic cells during differentiation in different cell groups was detected and analysed by flow cytometry. Propofol in different concentrations and LPS had low influence on the survival rate of spleen dendritic cells. It inhibited the expression of inflammatory cytokines and significantly lowered the expression level of dendritic cells during differentiation in a dose-dependent manner.
第一作者机构：[1]Hebei Univ, Dept Anaesthesiol, Affiliated Hosp, Baoding 071000, Hebei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Pan Xuanyi,Yuan Lili,Yang Meili,et al.EFFECTS OF PROPOFOL ON THE DIFFERENTIATION OF NORMAL SPLEEN DENDRITIC CELLS TO IMMUNE CELLS AND ITS MECHANISM OF ACTION[J].FARMACIA.2017,65(3):429-434.
APA：
Pan, Xuanyi,Yuan, Lili,Yang, Meili&Liu, Caihua.(2017).EFFECTS OF PROPOFOL ON THE DIFFERENTIATION OF NORMAL SPLEEN DENDRITIC CELLS TO IMMUNE CELLS AND ITS MECHANISM OF ACTION.FARMACIA,65,(3)
MLA：
Pan, Xuanyi,et al."EFFECTS OF PROPOFOL ON THE DIFFERENTIATION OF NORMAL SPLEEN DENDRITIC CELLS TO IMMUNE CELLS AND ITS MECHANISM OF ACTION".FARMACIA 65..3(2017):429-434
