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Stimuli-responsive chitosan based nanoparticles in cancer therapy and diagnosis: A review

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机构： [1]Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Department of Medical Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei, China. [2]Department of Joint Surgery, Southwest Hospital, Army Medical University, Third Military Medical University, Chongqing 400038, PR China. [3]School of Basic Medicine, Hebei Medical University, Shijiazhuang, China. [4]Department of Gastroenterology, The Second Affiliated Hospital of Nanchang University, Nanchang, China. [5]School of Medicine, Tongji university, Shanghai 200092, China. Electronic address: xiujuansh@tongji.edu.cn. [6]The Laboratory for Tumor Molecular Diagnosis, Peking University Cancer Hospital, Inner Mongolia Campus, Afliated Cancer Hospital of Inner Mongolia Medical University, Hohhot 010020, China. Electronic address: ndwzf2013@126.com. [7]Department of Ophthalmology, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, Liaoning, China. Electronic address: Pengsun.oph@hotmail.com.

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关键词： Chitosan cancer therapy Nanoparticles

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Chitosan, obtained through deacetylation of chitin, has been shown to a promising biopolymer for the development of nano- and micro-particles. In spite of inherent anti-cancer activity of chitosan, the employment of this carbohydrate polymer for the synthesis of nanoparticles opens a new gate in disease therapy. The properties of chitosan including biocompatibility, biodegradability, and modifiability are vital in enhancing these nanoparticles, allowing for improved solubility and interaction with cellular targets. Among the pathological events, cancer has demonstrated an increase in incidence rate and therefore, the chitosan nanoparticles have been significantly utilized in cancer therapy. The present review emphasizes on the role of stimuli-responsive chitosan nanoparticles in the field of cancer therapy. The stimuli-responsive nanoparticles can release the cargo in the tumor site that not only improves the anti-cancer activity of chemotherapy drugs, but also diminishes their systemic toxicity. The stimuli-responsive chitosan nanoparticles can respond to endogenous and exogenous stimuli including pH, redox and light to release cargo. This improves the specificity towards tumor cells and enhances accumulation of drugs and/or drugs. The light-responsive chitosan nanoparticles can cause photothermal and photodynamic therapy in tumor ablation and provide theranostic feature that is cancer diagnosis and therapy simultaneously.Copyright © 2024 Elsevier B.V. All rights reserved.

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大类 | 2 区

生物学

小类 | 2 区生化与分子生物学 2 区应用化学 2 区高分子科学

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Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Q1 CHEMISTRY, APPLIED Q1 POLYMER SCIENCE

影响因子： 7.7 最新[2023版] 7.7 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 7.7 出版前一年[2023版]

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第一作者机构： [1]Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Department of Medical Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei, China.

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Stimuli-responsive chitosan based nanoparticles in cancer therapy and diagnosis: A review

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