Endothelial growth factor receptor-targeted and reactive oxygen species-responsive lung cancer therapy by docetaxel and resveratrol encapsulated lipid-polymer hybrid nanoparticles
机构：[1]Chinese Peoples Liberat Army Gen Hosp, Dept Med Oncol, Beijing 100853, Peoples R China[2]Hebei Univ,Affiliated Hosp,Dept Med Oncol,Baoding 071000,Hebei,Peoples R China医疗肿瘤内科河北大学附属医院重点学科肿瘤内科
Special targeted therapy like endothelial growth factor receptor (EGFR) targeted therapy is available for the treatment of advanced non-small cell lung cancer (NSCLC). Biodegradable core-shell lipid-polymer hybrid nanoparticles (LPNs) can combine the beneficial properties of lipid and polymeric NPs for controlled drug delivery. In the present study, epidermal growth factor (EGF) conjugated LPNs were fabricated to co-deliver docetaxel (DTX) and resveratrol (RSV). In vitro and in vivo studies demonstrated that EGF DTX/RSV LPNs have significant synergistic effects, best tumor inhibition ability and the lowest systemic toxicity. The results indicate that EGF DTX/RSV LPNs may be a promising strategy for treatment of NSCLC.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2018]版：
Q1PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Chinese Peoples Liberat Army Gen Hosp, Dept Med Oncol, Beijing 100853, Peoples R China[2]Hebei Univ,Affiliated Hosp,Dept Med Oncol,Baoding 071000,Hebei,Peoples R China
通讯作者：
通讯机构：[1]Chinese Peoples Liberat Army Gen Hosp, Dept Med Oncol, Beijing 100853, Peoples R China[*1]Chinese Peoples Liberat Army Gen Hosp, 28 Fuxing Rd, Beijing 100853, Peoples R China
推荐引用方式(GB/T 7714)：
Song Zizheng,Shi Yan,Han Quanli,et al.Endothelial growth factor receptor-targeted and reactive oxygen species-responsive lung cancer therapy by docetaxel and resveratrol encapsulated lipid-polymer hybrid nanoparticles[J].BIOMEDICINE & PHARMACOTHERAPY.2018,105:18-26.doi:10.1016/j.biopha.2018.05.095.
APA：
Song, Zizheng,Shi, Yan,Han, Quanli&Dai, Guanghai.(2018).Endothelial growth factor receptor-targeted and reactive oxygen species-responsive lung cancer therapy by docetaxel and resveratrol encapsulated lipid-polymer hybrid nanoparticles.BIOMEDICINE & PHARMACOTHERAPY,105,
MLA：
Song, Zizheng,et al."Endothelial growth factor receptor-targeted and reactive oxygen species-responsive lung cancer therapy by docetaxel and resveratrol encapsulated lipid-polymer hybrid nanoparticles".BIOMEDICINE & PHARMACOTHERAPY 105.(2018):18-26
