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Semaglutide mitigates testicular damage in diabetes by inhibiting ferroptosis

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机构： [1]Department of Pharmacology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of New Drug Pharmacology and Toxicology, The Hebei Collaboration Innovation Center for Mechanism, Diagnosis and Treatment of Neurological and Psychiatric Disease, Hebei Medical University, Shijiazhuang, 050017, China [2]Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050017, China [3]Department of General Practice, The Affiliated Hospital of Hebei University of Science and Technology, Shijiazhuang, 050018, China [4]Graduate School of Hebei Medical University, Shijiazhuang, 050017, China [5]College of Basic Medicine, Hebei Medical University, Shijiazhuang, 050017, China

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关键词： Semaglutide Diabetes mellitus Testicular damage Ferroptosis Lipid peroxidation ROS Mitochondrial membrane potentia

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Diabetes is linked to male infertility, but the mechanisms and therapeutic options remain unclear. This study investigates the effects of semaglutide on testicular function in a diabetes mouse model. Clinical data shows that diabetes affects blood glucose, lipid levels, and sperm quality. Single-cell and transcriptome analyses reveal changes in testicular tissue cell proportions and activation of ferroptosis pathways in diabetic patients/rats. In the diabetes mouse model, sperm quality decreases significantly. Treatment with semaglutide (Sem) and the ferroptosis inhibitor ferrostatin-1 (Fer-1) alleviates testicular damage, as evidenced by improved lipid peroxidation and ferroptosis markers. Moreover, the diabetes-induced decrease in the TM-3 cell line's vitality, increased lipid peroxidation, ROS, ferrous ions, and mitochondrial membrane potential damage are all improved by semaglutide and ferrostatin-1 intervention. Overall, these findings highlight semaglutide's potential as a therapeutic approach for mitigating diabetes-induced testicular damage through modulation of the ferroptosis pathway.Copyright © 2024 Elsevier Inc. All rights reserved.

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大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

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最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 0 出版当年[2024版] 0 出版当年五年平均 2.5 出版前一年[2023版]

第一作者：

第一作者机构： [1]Department of Pharmacology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education, The Key Laboratory of New Drug Pharmacology and Toxicology, The Hebei Collaboration Innovation Center for Mechanism, Diagnosis and Treatment of Neurological and Psychiatric Disease, Hebei Medical University, Shijiazhuang, 050017, China [2]Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, 050017, China

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Semaglutide mitigates testicular damage in diabetes by inhibiting ferroptosis

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