机构：[1]Department of Laboratory,Affiliated Hospital of Hebei University, Baoding, 071000, China.河北大学附属医院[2]Department of Neurological Examination,Affiliated Hospital of Hebei University, Baoding,071000,China.河北大学附属医院
The objective of this study was to analyze the effectiveness of capillary electrophoresis detection of hemoglobin electrophoresis (HE) for the early screening of thalassemia. In the first choice, 974 pregnant women were selected for capillary electrophoresis to detect HE, which showed that 46 of them were abnormal (4.72%), including 16 cases with HbA2<2.5% and 28 cases with HbA2>3.5% and/or HbF≥2.0%. In one case each of HbH and HbBart's abnormal bands was found. The genotype test results showed the presence of thalassemia in 34 cases, using the genotype test results as the gold standard, after calculation it was seen that capillary electrophoresis for HE diagnosis of the occurrence of thalassemia had a sensitivity and specificity of 54.34% and 70.97% (P<0.05). These results suggest that in the screening of thalassemia in northern China, capillary electrophoresis for HE has good application and can be used as one of the routine screening tools, but further confirmation by genotype testing is still needed.
基金：
Baoding City Science and
Technology Plan Project(NO.2141ZF313).
第一作者机构：[1]Department of Laboratory,Affiliated Hospital of Hebei University, Baoding, 071000, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Lin Meilin,Meng Yanan,Wang Yan,et al.Early screening of thalassemia in pregnant women in northern China by capillary electrophoresis for the determination of hemoglobin electrophoresis[J].CELLULAR AND MOLECULAR BIOLOGY.2023,69(10):174-178.doi:10.14715/cmb/2023.69.10.25.
APA：
Lin Meilin,Meng Yanan,Wang Yan,Zheng Hailiang,Liang Shuxing...&Yan Shuai.(2023).Early screening of thalassemia in pregnant women in northern China by capillary electrophoresis for the determination of hemoglobin electrophoresis.CELLULAR AND MOLECULAR BIOLOGY,69,(10)
MLA：
Lin Meilin,et al."Early screening of thalassemia in pregnant women in northern China by capillary electrophoresis for the determination of hemoglobin electrophoresis".CELLULAR AND MOLECULAR BIOLOGY 69..10(2023):174-178
