Cervical cancer is a common malignancy, and miR-134 involves in multiple tumors. The present study aims to explore its expression and role in cervical cancer. miR-134 level in cervical cancer and para-carcinoma tissues was detected by RT-PCR. Cells were transfected with miR-134 mimics or inhibitor followed by measuring cell behaviors. The results of bioinformatics analysis showed that miR-134 targeted the downstream CTTN. miR-134 inhibited the biological behaviors of cervical cancer cells through suppressing the downstream cell division cycle 42 (Cdc42)/neural Wiskott-Aldrich syndrome protein (N-WASP) signals. Moreover, miR-134, through regulating CTTN, negatively regulated invasion and inhibited the degradation of extracellular matrix in cervical cancer cells. In conclusion, miR- 134 targets CTTN to inhibit the invasion of cervical cancer, thereby inhibiting metastasis.
第一作者机构：[1]Handan First Hosp, Dept Obstet & Gynecol, Handan City 056000, Hebei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Zhu Fang,Li Yachai,Li Xiaodan.miR-134 Inhibits Cervical Cancer Cell Invasion via Targeting Cortactin[J].JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING.2022,12(12):2407-2412.doi:10.1166/jbt.2022.3192.
APA：
Zhu, Fang,Li, Yachai&Li, Xiaodan.(2022).miR-134 Inhibits Cervical Cancer Cell Invasion via Targeting Cortactin.JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING,12,(12)
MLA：
Zhu, Fang,et al."miR-134 Inhibits Cervical Cancer Cell Invasion via Targeting Cortactin".JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING 12..12(2022):2407-2412
