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Dyclonine relieves the Parkinson's disease progression in rotenone-induced Drosophila model

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机构: [1]Hebei Univ, Sch Basic Med Sci, Baoding, Peoples R China [2]Hebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China [3]Hebei Univ, Affiliated Hosp, Dept Anesthesiol, Baoding, Peoples R China [4]Hebei Univ, Sch Basic Med Sci, Baoding 071000, Hebei, Peoples R China [5]Hebei Univ, Affiliated Hosp, Dept Neurol, Baoding 071000, Hebei, Peoples R China
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关键词: Parkinson's disease Dyclonine Oxidative stress Nuclear factor E2-related factor 2

摘要:
It has been estimated that there will be 930 million Parkinson's disease (PD) patients in 2030 in the whole world. However, no therapy has been effective for PD until now. Only levodopa is the available primary drug for the treatment of motor symptoms. Therefore, it is an urgent task to develop new drugs to inhibit the progression of PD and improve the quality of the patient's life. Dyclonine which was found to have antioxidant activity and would benefit patients with Friedreich's ataxia, is a commonly used local anesthetic. Here, we reported that dyclonine improved the motor ability and loss of dopaminergic neurons in the rotenone-induced Drosophila PD model for the first time. Furthermore, dyclonine upregulated the Nrf2/HO pathway, decreased the ROS and MDA levels, and inhibited the apoptosis of neurons in the brain of PD model flies. Hence, dyclonine might be an attractive FDA-approved drug for the exploration of effective PD therapy.

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出版当年[2025]版:
大类 | 3 区 心理学
小类 | 3 区 行为科学 4 区 神经科学
最新[2025]版:
大类 | 3 区 心理学
小类 | 3 区 行为科学 4 区 神经科学
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出版当年[2023]版:
Q2 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES
最新[2023]版:
Q2 BEHAVIORAL SCIENCES Q3 NEUROSCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2023版] 出版当年五年平均 出版前一年[2022版]

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第一作者机构: [1]Hebei Univ, Sch Basic Med Sci, Baoding, Peoples R China
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通讯机构: [1]Hebei Univ, Sch Basic Med Sci, Baoding, Peoples R China [2]Hebei Univ, Affiliated Hosp, Dept Neurol, Baoding, Peoples R China [4]Hebei Univ, Sch Basic Med Sci, Baoding 071000, Hebei, Peoples R China [5]Hebei Univ, Affiliated Hosp, Dept Neurol, Baoding 071000, Hebei, Peoples R China
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