机构：[1]Department of Head and Neck Surgery, Affiliated Hospital of Hebei University, Baoding, China河北大学附属医院[2]Administration Office of Medical Record, Affiliated Hospital of Hebei University, Baoding, China河北大学附属医院
Aim: Thyroid cancer accounts for 3.8% of the total endocrine cancer and is the fifth most diagnosed cancer among Indian women. Geraniol possesses pharmacological properties, including anti-inflammatory, anti-cancer, and neuroprotective properties. The anti-cancer activity of geraniol on TPC-1 cells was assessed in this study. Materials and Methods: The anticancer activity of geraniol in TPC-1 cells was evaluated by MTT test, ROS, DAPI, PI, and AO/EB staining. mRNA and expression were assessed by qPCR and western blot. Results: The geraniol has shown cytotoxic effects toward TPC-1 cells and showed an IC50 value of 25 mu M, which decreases cell viability and inhibited cell proliferation. It also increased the accumulation of intracellular ROS, which induces apoptosis in the TPC-1 cells due to the dissipation of membrane potential and disruption of mitochondria. There is a substantial reduction in the mRNA level expressions of Bcl-2, Cyclin D1, c-Myc, COX-2, TNF-alpha, NF-kappa B, IL-6, and surviving. It also upregulated the Bax and caspase-3 mRNA expression suggesting cell death-mediated apoptosis. Conclusion: We report that geraniol effectively inhibited the JAK-2, STAT-3, and ERK signaling pathways depicting geraniol as a potential therapeutic molecule for thyroid cancer treatment.
第一作者机构：[1]Department of Head and Neck Surgery, Affiliated Hospital of Hebei University, Baoding, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Head and Neck Surgery, Affiliated Hospital of Hebei University, Baoding, China[*1]Department of Head and Neck Surgery, AffiliatedHospital of Hebei University, Baoding - 071000,China
推荐引用方式(GB/T 7714)：
Yang Hongli,Zhang Yonggang,Cui Jianying,et al.Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells[J].PHARMACOGNOSY MAGAZINE.2022,18(80):1183-1189.doi:10.4103/pm.pm_223_21.
APA：
Yang, Hongli,Zhang, Yonggang,Cui, Jianying&Hao, Zhi.(2022).Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells.PHARMACOGNOSY MAGAZINE,18,(80)
MLA：
Yang, Hongli,et al."Apoptosis-Mediated Anticancer Activity of Geraniol Inhibits NF-κB, MAPK, and JAK-STAT-3 Signaling Pathways in Human Thyroid Cancer Cells".PHARMACOGNOSY MAGAZINE 18..80(2022):1183-1189
