Objective: To investigate the incidence and influencing factors of mild cognitive impairment(MCI) in patients with nonvalvular atrial fibrillation (AF) with no history of stroke and normal heart function aged over 60 years, in order to provide evidence for early intervention in elderly patients with non-valvular atrial fibrillation combined with MCI to reduce the risk of dementia. Methods; A total of 265 patients with non-valvular atrial fibrillation without stroke history and normal heart function were randomly included. Montreal cognitive assessment (MoCA) was used to test the; cognitive function of patients, and activity of daily living (ADL) was used to test;the daily living ability,of patients. According to both MoCA and ADL scale scores, the patients Were divided into AF combined with mild cognitive function group (MCI group): MoCA score (15 similar to 26), ADL scale score <26; Normal AF cognitive function group (control group): MoCA score >= 26, ADL scale score <26. We evaluated the incidence of mild cognitive impairment and impairment of the. cognitive domain, and explored both risk and protective factors of AF with MCI Results: (1) The comparison of data between the two groups in age, proportion of C1-1A2DS2-VASe score (male >= 2, female >= 3), proportion of taking anticoagulant drugs and proportion of taking statins. (2)Among 265 patients with AF 110 (41.5%) developed MCI. Compared with the control group, the total score ofItloCA, visual space and executive function, delayed memory, naming power and attention were significantly decreased in the MCI group (P < 0.05). (3) Logistic multivariate regression analysis was perform.ed. Age (OR: 1.09, 95%CI: 1.03-1.16, P=0.004), CHA2DS2-VASc score (OR: 2.22, 95%Cl: 1.14-4.34, P=0.02.) were independent riskfactors for AIC1, education level above middle school (OR: 0.20, 95' Cl: 0.08-0.53, P=0.001) and use of anticoagulant drugs (OR: 0.43, 95%CI:0.24-0.7, P=0.004) was a protective factor for MCI. Conclusion: Patients with atrial fibrillation have a higher incidence of MCI, particularly visual space and executivefunction, delayed memory, naming power and attenttonal decline. In addition, age and CI1A2DS2-VASc score were independent risk factors for M with atrial fibrillation, whereas educattort level above middle school and the use of anticoagulant drugs were protectivefactorsinrs fPoarilMenCis wl MCI in Patients with atrial fibrillation.