机构：[1]State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, CollaborativeInnovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, Tianjin 300071, PR China[2]Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science & Peking Union MedicalCollege, Tianjin 300192, PR China[3]College of Medicine, The Affiliated Hospital, Hebei University, Baoding 071000, PR China
Recently, zwitterionic materials have been developed as alternatives to PEG for prolonging the circulation time of nanoparticles without triggering immune responses. However, zwitterionic coatings also hindered the interactions between nanoparticles and tumor cells, leading to less efficient uptake of nanoparticles by cancer cells. Such effect significantly limited the applications of zwitterionic materials for the purposes of drug delivery and the development to novel therapeutic agents. To overcome these issues, surface-adaptive mixed-shell micelles (MSMs) with poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)/poly(beta-amino ester) (PAE) heterogeneous surfaces were constructed. Owing to the synergistic effect of zwitterionic coatings and micro-phase-separated surfaces, PMPC mixed-shell micelles exhibited the improved blood circulation time compared to single-PEG-shell micelles (PEGSMs) and single-PMPC-shell micelles (PMPCSMs). Moreover, such. MSMs can convert their surface to positively charged ones in response to the acidic tumor microenvironment, leading to a significant enhancement in cellular uptake of MSMs by tumor cells. This strategy demonstrated a general approach to enhance the cellular uptake of zwitterionic nanoparticles without compromising their long circulating capability, providing a practical method for improving the tumor-targeting efficiency of particulate drug delivery systems. (C) 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
基金：
National Natural Science Foundation of China [51390483, 91527306, 51673100, 51473044]; Thousand Talents Program for Young Professionals, PCSIRT [IRT1257]; Fundamental Research Funds for the Central Universities
第一作者机构：[1]State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, CollaborativeInnovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, Tianjin 300071, PR China
通讯作者：
推荐引用方式(GB/T 7714)：
Ou Hanlin,Cheng Tangjian,Zhang Yumin,et al.Surface-adaptive zwitterionic nanoparticles for prolonged blood circulation time and enhanced cellular uptake in tumor cells[J].ACTA BIOMATERIALIA.2018,65:339-348.doi:10.1016/j.actbio.2017.10.034.
APA：
Ou, Hanlin,Cheng, Tangjian,Zhang, Yumin,Liu, Jinjian,Ding, Yuxun...&Shi, Linqi.(2018).Surface-adaptive zwitterionic nanoparticles for prolonged blood circulation time and enhanced cellular uptake in tumor cells.ACTA BIOMATERIALIA,65,
MLA：
Ou, Hanlin,et al."Surface-adaptive zwitterionic nanoparticles for prolonged blood circulation time and enhanced cellular uptake in tumor cells".ACTA BIOMATERIALIA 65.(2018):339-348
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