MicroRNAs (miRNAs) play a critical role in glioblastoma initiation and progression. PIWILI, a human homolog of the PIWI family, has a critical effect on glioblastoma progression. In present study, we found that the expression of miR-154-5p was significantly lower in glioblastoma. Our results suggested that the overexpression of miR-154-5p suppressed proliferation and metastasis, induced apoptosis, whereas inhibiting the expression of miR-154-5p significantly promoted proliferation and metastasis of glioblastoma. We further proved that miR-154-5p directly integrated with the 3 '-UTR of PIWILI and reintroduction of PIWIL1 can rescue the phenotype changes induced by miR-154-5p. Taken together, our study reveals that miR-154-5p can counteract the malignant phenotypes of glioblastoma by targeting PIWIL1, which might be beneficial to reveal new therapeutic targets for glioblastoma. (C) 2017 Published by Elsevier B.V.
基金：
Foundation of Tianjin Science and Technology Committee [14JCZDJC35600]; National Key Technology Support Program [2014BA104B00, 2015BA103B05]
Wang Xiuyu,Sun Shupeng,Tong Xiaoguang,et al.MiRNA-154-5p inhibits cell proliferation and metastasis by targeting PIWIL1 in glioblastoma[J].BRAIN RESEARCH.2017,1676:69-76.doi:10.1016/j.brainres.2017.08.014.
APA：
Wang, Xiuyu,Sun, Shupeng,Tong, Xiaoguang,Ma, Quanfeng,Di, Hui...&Wang, Jinhuan.(2017).MiRNA-154-5p inhibits cell proliferation and metastasis by targeting PIWIL1 in glioblastoma.BRAIN RESEARCH,1676,
MLA：
Wang, Xiuyu,et al."MiRNA-154-5p inhibits cell proliferation and metastasis by targeting PIWIL1 in glioblastoma".BRAIN RESEARCH 1676.(2017):69-76
