Immoderate immunoreaction of antigen-specific Th17 and Treg cell dysfunction play critical roles in the pathogenesis of multiple sclerosis. We examined Th17/Treg immune responses and the underlying mechanisms in response to metformin in C57BL/6 mice with experimental autoimmune encephalomyelitis (EAE). Metformin reduced Th17 and increased Treg cell percentages along with the levels of associated cytokines. Molecules involved in cellular metabolism were altered in mice with EAE. Suppressed activation of mTOR and its downstream target, HIF-la, likely mediated the protective effects of metformin. Our findings demonstrate that regulation of T cell metabolism represents a new therapeutic target for CNS autoimmune disorders. (C) 2016 Elsevier B.V. All rights reserved.
第一作者机构：[1]Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang 050000, Hebei, Peoples R China
通讯作者：
通讯机构：[1]Hebei Med Univ, Hosp 2, Dept Neurol, Shijiazhuang 050000, Hebei, Peoples R China[4]Key Lab Hebei Neurol, Shijiazhuang 050000, Hebei, Peoples R China[*1]Hebei Med Univ, Key Lab Hebei Neurol, Hosp 2, Dept Neurol, Heping Xi Rd 215, Shijiazhuang 050000, Hebei Province, Peoples R China
推荐引用方式(GB/T 7714)：
Sun Yafei,Tian Tian,Gao Juan,et al.Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice[J].JOURNAL OF NEUROIMMUNOLOGY.2016,292:58-67.doi:10.1016/j.jneuroim.2016.01.014.
APA：
Sun, Yafei,Tian, Tian,Gao, Juan,Liu, Xiaoqian,Hou, Huiqing...&Guo, Li.(2016).Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice.JOURNAL OF NEUROIMMUNOLOGY,292,
MLA：
Sun, Yafei,et al."Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice".JOURNAL OF NEUROIMMUNOLOGY 292.(2016):58-67
