Kruppel-like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes. The aim of this study was to reveal the functions of KLF4 in regulating breast cancer apoptosis, proliferation, and tumorigenic progression. KLF4 expression levels in breast cancer tissues and breast cancer cell lines were found to be much lower than those in nontumorous tissues and a nontransformed mammary epithelial cell line. KLF4 was upregulated in the tumor necrosis factor-a-induced SK-BR-3 breast cancer cell apoptotic process. Overexpression of KLF4 promoted SK-BR-3 breast cancer cell apoptosis and suppressed SK-BR-3 cell tumorigenicity in vivo. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies. This is an open access article under the CC BY-NC-ND license
基金：
National Natural Science Foundation of China [31301143]; Natural Science Foundation of Hebei Province [C2013201271]; Hebei Youth Top-notch Talent Support Program
第一作者机构：[1]Hebei Univ, Affiliated Hosp, Dept Oncol, Baoding 071000, Peoples R China
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推荐引用方式(GB/T 7714)：
Wang Bing,Zhao Ming-zhi,Cui Nai-peng,et al.Kruppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells[J].FEBS OPEN BIO.2015,5:147-154.doi:10.1016/j.fob.2015.02.003.
APA：
Wang, Bing,Zhao, Ming-zhi,Cui, Nai-peng,Lin, Dan-dan,Zhang, An-yi...&Chen, Bao-ping.(2015).Kruppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells.FEBS OPEN BIO,5,
MLA：
Wang, Bing,et al."Kruppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells".FEBS OPEN BIO 5.(2015):147-154
