Objective To establish a diagnostic model of idiopathic central precocious puberty on the basis of transrectal pelvic ultrasound and basal gonadotropin. Methods A total of 669 girls with Tanner breast development stage II were enrolled in this study from January 2015 to December 2018. The participants were divided into the ICPP group and the premature thelarche group. We analyzed various variables, including age at initial diagnosis, basal luteinizing hormone levels, the long diameter of the uterus, the transverse diameter of the uterus, the anterior-posterior diameter of the uterus, the volume of the uterus, maximum ovarian diameter, average ovarian volume, maximum ovarian volume, number of follicles (>= 4 mm), maximum follicular diameter, endometrial thickness, and vaginal wall thickness. Results The following diagnostic model was established: Y=-14.123 + 0.630 x age at initial diagnosis + 1.119 x transverse diameter of the uterus + 1.278 x anterior-posterior diameter of the uterus + 0.637 x average ovarian volume + 1.316 x maximum ovarian diameter + 0.146 xnumber of follicles >= 4 mm + 2.925 x endometrial thickness + 0.559 x basal luteinizing hormone value. The area under curve was 0.922, sensitivity was 84.9%, and specificity was 86.2%. Conclusion Basal LH levels and transrectal pelvic ultrasound should be applied together to improve the accuracy of diagnosis in ICPP.
基金：
Hebei Excellent Talents Project; Hebei Provincial Science and Technology Department Project [09276102D-1]; Baoding Science and Technology Plan Project [18ZF058]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
最新[2025]版：
大类|4 区医学
小类|4 区医学：研究与实验4 区药学
JCR分区：
出版当年[2020]版：
Q4PHARMACOLOGY & PHARMACYQ4MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q4MEDICINE, RESEARCH & EXPERIMENTALQ4PHARMACOLOGY & PHARMACY
第一作者机构：[1]Hebei Univ, Dept Pediat, Affiliated Hosp, Baoding, Peoples R China
通讯作者：
通讯机构：[2]Hebei Med Univ, Dept Pediat, Hosp 2, 215 Heping Xi Rd, Shijiazhuang 050051, Hebei, Peoples R China[*1]Department of Pediatrics, The Second Hospital of Hebei Medical University, No. 215 Heping Xi Road, Xinhua District, Shijiazhuang 050051, China
推荐引用方式(GB/T 7714)：
Yuan Bo,Pi Ya-Lei,Zhang Ya-Nan,et al.A diagnostic model of idiopathic central precocious puberty based on transrectal pelvic ultrasound and basal gonadotropin levels[J].JOURNAL OF INTERNATIONAL MEDICAL RESEARCH.2020,48(8):doi:10.1177/0300060520935278.
APA：
Yuan, Bo,Pi, Ya-Lei,Zhang, Ya-Nan,Xing, Peng,Chong, He-Meng&Zhang, Hui-Feng.(2020).A diagnostic model of idiopathic central precocious puberty based on transrectal pelvic ultrasound and basal gonadotropin levels.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,48,(8)
MLA：
Yuan, Bo,et al."A diagnostic model of idiopathic central precocious puberty based on transrectal pelvic ultrasound and basal gonadotropin levels".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 48..8(2020)
