研究单位：[1]Peking University First Hospital[2]Affiliated Hospital of Hebei University[3]Beijing Miyun Hospital[4]Dongzhimen Hospital, Beijing University of Chinese Medicine[5]Taiyuan Central Hospital of Shanxi Medical University[6]Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing,Beijing,China,100007[7]Peking University First Hospital,Beijing,Beijing,China,100034[8]Beijing Miyun District Hospital,Beijing,Beijing,China,101520[9]Affliated Hospital of Hebei University,Baoding,Hebei,China,071000[10]Taiyuan Central Hospital,Taiyuan,Shanxi,China,030009
The goal of this observational cross-sectional study is to develop a clinical diagnostic system for intrinsic acute kidney disease (AKD) to help clincians make non-invasive diagnosis when a kidney biopsy is not available. The main questions it aims to answer are: 1. Can a clinical model comprised of common clinical indexes help diagnose AKD ? 2. Can a combinition of several urinary biomarkers help diagnose AKD ? The study will be conducted in retrospective cohorts of patients with AKD undergoing kidney biopsy. The gold standard of the study is histological diagnosis of AKD. The model will be developed in a derivation cohort from one center, and will be further externally validated in a multicent cohort. The urinary biomarkers will only be tested in the derivation cohort.
