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Synthesis, Characterization, and Cytotoxicity of New Types of Binuclear Platinum(II) Complexes

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机构： [1]Hebei Univ, Biol Chem Lab, Coll Chem & Environm Sci, Baoding, Peoples R China [2]Hebei Univ, Affiliated Hosp, Baoding, Peoples R China [3]Hebei Med Univ, Dept Sci & Technol, Shijiazhuang, Peoples R China

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关键词： binuclear platinum(II) complexes characterization cytotoxicity synthesis

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Four new types of iodo-bridged binuclear platinum complexes [Pt2AI5] (A = dimethylamine, pyridine, 2-methylpyridine, and o-toluidine) (a-d) have been synthesized and characterized by elemental analysis, conductivity, thermal analysis, IR, 1H NMR, and mass spectra techniques. The cytotoxicity was investigated by MTT assay. The results indicate that complexes (a-d) have certain cytotoxicity against Bel-7402, HCT-8 and Hela cell lines. The complex a, c, and d display increased cytotoxicity than cisplatin against HCT-8, Bel-7402 and Hela cell lines, respectively. The results suggest that these complexes have selectivity against the tested carcinoma cell lines, with the amine ligand having an important effect on the cytotoxicity.

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出版当年[2011]版：

大类 | 4 区工程技术

小类 | 4 区无机化学与核化学 4 区纳米科技

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无

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出版当年[2010]版：

Q4 NANOSCIENCE & NANOTECHNOLOGY Q4 CHEMISTRY, INORGANIC & NUCLEAR

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无

影响因子： 0 最新[2023版] 0 最新五年平均 0.504 出版当年[2010版] 0.579 出版当年五年平均 0.569 出版前一年[2009版] 0.467 出版后一年[2011版]

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第一作者机构： [1]Hebei Univ, Biol Chem Lab, Coll Chem & Environm Sci, Baoding, Peoples R China

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