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Correlations of Serum MMP-9, TIMP-1, TGF-β and bFGF Levels with Atrial Fibrillation in Patients without Structural Heart Disease

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机构: [1]Capital Med Univ, Beijing Chaoyang Hosp, Dept Cardiol, Beijing 100000, Peoples R China [2]Shijiazhuang Peoples Hosp, Dept Cardiol, Shijiazhuang 050000, Hebei, Peoples R China [3]Hebei Univ,Dept Cardiol,Affiliated Hosp,Baoding 071000,Peoples R China
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关键词: Atrium Cardiac Ultrasonography Cytokine Prediction Prognosis

摘要:
The researchers aimed in highlighting the correlations of serum MMP-9, TIMP-1, TGF-beta 1 and bFGF levels with atrial fibrillation (AF) within diseased persons showing no structural heart ailment. A total of 236 eligible diseased persons had been categorized within AF category (n=168) and non-AF category (n=68). Left atrial diameter (LAD), left ventricular end-diastolic dimension (LVEDD) and left ventricular ejection fraction (LVEF) had been measured through cardiac ultrasonography. Comparing concerning non-AF category, AF class had larger LAD and smaller LVEF (P<0.01). MMP-9 and TGF-beta 1 levels had been higher while TIMP-1 level remained less within AF class as compared to non-AF class (P<0.01). Age, LVEF and left atrial MMP-9/TIMP-1 remained free correlative factors of AF (P<0.01). MMP-9/TIMP-1 remained definitely correlated concerning LAD within AF class (r=0.509, P<0.01). Left atrial MMP-9/TIMP-1 remained higher within diseased persons regarding persistent AF (P<0.01). Left atrial MMP-9/TIMP-1 is correlated with AF within diseased persons having no structural heart ailment, particularly in the case of persistent AF.

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出版当年[2022]版:
大类 | 4 区 生物学
小类 | 4 区 遗传学
最新[2025]版:
大类 | 4 区 生物学
小类 | 4 区 遗传学
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出版当年[2021]版:
Q4 GENETICS & HEREDITY
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Q4 GENETICS & HEREDITY

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第一作者机构: [1]Capital Med Univ, Beijing Chaoyang Hosp, Dept Cardiol, Beijing 100000, Peoples R China [2]Shijiazhuang Peoples Hosp, Dept Cardiol, Shijiazhuang 050000, Hebei, Peoples R China
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