机构：[1]Emergency Medicine, Affiliated Hospital of Hebei University, Baoding 071000, China[2]Gastrointestinal Surgery, Affiliated Hospital of Hebei University, Baoding 071000, China[3]Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding 071000, China
Objective: To study the mechanism of lncRNA p21 inhibiting the growth and metastasis of human gastric cancer
SGC7901/GES-1 cells by mediating the Wnt/β-catenin signaling pathway. Methods: Lentiviral overexpression of lncRNAp21 in human gastric cancer SGC7901/GES-1 cell transfections was observed and analyzed for in vitro migration, invasion,
cell morphology and proliferation. Besides. Wnt/β-catenin signaling pathway was tested for direct involvement in lncRNAp21-mediated inhibition of gastric cancer cell growth and proliferation. Wnt/β-catenin signaling pathway was validated using
Li-C1. Results: Gastric cancer SGC7901/GES-1 cells in the overexpression of lncRNA-p21 showed changes in stellate
morphology, low invasion, or spindle-shaped morphology. LncRNA-p21 inhibited the growth and proliferation of gastric
cancer SGC7901/GES-1 cells both in vivo and in vitro, and Wnt/β-catenin signaling pathway mediated the proliferation,
invasion, and migration of lncRNA-p21 on gastric cancer SGC7901/GES-1 cells. Conclusion: LncRNA-p21 can inhibit the
growth and metastasis of gastric cancer SGC7901/GES-1 cells in vitro and in vivo, and the inhibition of lncRNA p21 is mainly
mediated by inhibiting the Wnt/β-catenin signaling pathway.
语种：
外文
第一作者：
第一作者机构：[1]Emergency Medicine, Affiliated Hospital of Hebei University, Baoding 071000, China
共同第一作者：
通讯作者：
通讯机构：[1]Emergency Medicine, Affiliated Hospital of Hebei University, Baoding 071000, China[2]Gastrointestinal Surgery, Affiliated Hospital of Hebei University, Baoding 071000, China[3]Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Hebei University, Baoding 071000, China
推荐引用方式(GB/T 7714)：
Peng Liu,Haizhe Chang,Xinyu Peng,et al.The Role and Mechanism of LncRNA-p21 in Regulating Gastric Cancer Metastasis by Mediating Wnt/β-Catenin Signaling Pathway[J].Journal of Clinical and Nursing Research.2023,7(3):
APA：
Peng Liu,Haizhe Chang,Xinyu Peng,Xiu Zhang,Jianjun Zhang&Jiusong Luan.(2023).The Role and Mechanism of LncRNA-p21 in Regulating Gastric Cancer Metastasis by Mediating Wnt/β-Catenin Signaling Pathway.Journal of Clinical and Nursing Research,7,(3)
MLA：
Peng Liu,et al."The Role and Mechanism of LncRNA-p21 in Regulating Gastric Cancer Metastasis by Mediating Wnt/β-Catenin Signaling Pathway".Journal of Clinical and Nursing Research 7..3(2023)
