研究单位：[1]Beijing Tiantan Hospital[2]Beijing Tiantan Hospital[3]University of Melbourne[4]Taihe County Traditional Chinese Medicine Hospital,Fuyang,Anhui,China[5]Lixin County People''s Hospital,Haozhou,Anhui,China[6]Beijing Tian Tan Hospital, Capital Medical University,Beijing,Beijing,China,100070[7]First People''s Hospital of Tianshui,Tianshui,Gansu,China[8]Guangdong Second Provincial General Hospital,Guangzhou,Guangdong,China[9]Heyuan People''s Hospital,Heyuan,Guangdong,China[10]Huazhou People''s Hospital,Huazhou,Guangdong,China[11]Shaoguan Qujiang District People''s Hospital,Shaoguan,Guangdong,China[12]The Second Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou,China[13]The Second People''s Hospital of Guiyang,Guiyang,Guizhou,China[14]Qiandongnanzhou People''s Hospital,Qiandongnan,Guizhou,China[15]Haikou People''s Hospital,Haikou,Hainan,China[16]Affiliated Hospital of Hebei University,Baoding,Hebei,China[17]Qiu County People''s Hospital,Handan,Hebei,China[18]The Second Hospital of Qinhuangdao,Qinhuangdao,Hebei,China[19]Tangshan Guye Traditional Chinese Medicine Hospital,Tangshan,Hebei,China[20]Qinghe County People''s Hospital,Xingtai,Hebei,China[21]The 2nd Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,China[22]The First Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang,China[23]Hongxinglong Hospital of Beidahuang Group,Shuangyashan,Heilongjiang,China[24]Huaxian People''s Hospital of Henan,Anyang,Henan,China[25]Jiaozuo Coal Industry Central Hospital,Jiaozuo,Henan,China[26]The First People Hospital of Lingbao,Lingbao,Henan,China[27]Liuyang Jili Hospital,Liuyang,Henan,China[28]Nanshi Hospital of Nanyang,Nanyang,Henan,China[29]Nanle County People''s Hospital,Puyang,Henan,China[30]Nanle Zhongxing Hospital,Puyang,Henan,China[31]Puyang Oilfield General Hospital,Puyang,Henan,China[32]Guangshan County People''s Hospital,Xinyang,Henan,China[33]Xi County People''s Hospital,Xinyang,Henan,China[34]Taikang Xian People''s Hospital,Zhoukou,Henan,China[35]People''s Hospital of Queshan,Zhumadian,Henan,China[36]Zhumadian Traditional Chinese Medicine Hospital,Zhumadian,Henan,China[37]Chenzhou First People''s Hospital,Chenzhou,Hunan,China[38]The Fourth People''s Hospital of Chenzhou,Chenzhou,Hunan,China[39]Hengyang Central Hospital,Hengyang,Hunan,China[40]Keshketeng Banner Chinese-Mongolian Hospital,Keshketeng Banner,Inner Mongolia,China[41]Tongliao People''s Hospital,Tongliao,Inner Mongolia,China[42]Jiujiang First People''s Hospital,Jiujiang,Jiangxi,China[43]Jilin Electric Power Hospital,Changchun,Jilin,China[44]Siping City Central People''s Hospital,Siping,Jilin,China[45]Liuhe County People''s Hospital,Tonghua,Jilin,China[46]The First Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning,China[47]The People''s Hospital of Liaoning Province,Shenyang,Liaoning,China[48]The Second People''s Hospital of Dongying,Dongying,Shandong,China[49]Gaomi People''s Hospital,Gaomi,Shandong,China[50]Laizhou City People''s Hospital,Laizhou,Shandong,China[51]Linyi People''s Hospital,Linyi,Shandong,China[52]Qingdao Municipal Hospital,Qingdao,Shandong,China[53]The Second Affiliated Hospital of Shandong First Medical University,Taian,Shandong,China[54]The Affiliated Hospital of Shandong Second Medical University,Weifang,Shandong,China[55]Weifang People''s Hospital,Weifang,Shandong,China[56]Weihai Central Hospital,Weihai,Shandong,China[57]Yantai Taochun Central Hospital,Yantai,Shandong,China[58]Zaozhuang Municipal Hospital,Zaozhuang,Shandong,China[59]Linfen Central Hospital,Linfen,Shanxi,China[60]The First Affiliated Hospital, Zhejiang University School of Medicine,Hangzhou,Zhejiang,China[61]Ningbo Beilun District People''s Hospital,Ningbo,Zhejiang,China[62]Beijing Daxing District People''s Hospital,Beijing,China
研究目的：
The trial is a multicentre, prospective, open-label, blinded endpoint (PROBE), phase 3, randomized controlled design. Patients with acute ischemic stroke due to basilar artery occlusion presenting within 24 hours will be randomized 1:1 to intravenous tenecteplase (0.25mg/kg, maximum 25mg) ± thrombectomy or 'best practice'which may be alteplase (0.9mg/kg) within 4.5 hours from stroke onset or standard care (no lysis) ± thrombectomy at treating clinician's discretion.
