A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)
研究单位：[1]Amgen[2]University of Illinois Chicago,Chicago,Illinois,United States,60612[3]Norton Cancer Institute - Brownsboro,Louisville,Kentucky,United States,40241[4]University of New Mexico Cancer Center,Albuquerque,New Mexico,United States,87131[5]Memorial Sloan Kettering Cancer Center,New York,New York,United States,10065[6]Duke University,Durham,North Carolina,United States,27710[7]FirstHealth Cancer Center,Pinehurst,North Carolina,United States,28374[8]University of Pittsburgh Medical Center,Pittsburgh,Pennsylvania,United States,15232[9]University of Tennessee Medical Center Knoxville,Knoxville,Tennessee,United States,37920[10]Sarah Cannon Research Institute,Nashville,Tennessee,United States,37203[11]University of Texas MD Anderson Cancer Center,Houston,Texas,United States,77030[12]Hospital Britanico de Buenos Aires,Caba,Buenos Aires,Argentina,C1280AEB[13]Instituto Alexander Fleming,Capital Federal,Buenos Aires,Argentina,C1426ANZ[14]Instituto Argentino de Diagnostico y Tratamiento IADT,Ciudad Autónoma de Buenos Aires,Buenos Aires,Argentina,C1012AAR[15]Hospital Italiano de La Plata,La Plata,Buenos Aires,Argentina,B1900AUR[16]Fundacion Ars Medica,San Salvador de Jujuy,Jujuy,Argentina,4600[17]Clinica Viedma,Viedma,Río Negro,Argentina,8500[18]Sanatorio Parque SA,Rosario,Santa Fe,Argentina,2000[19]Centro Oncologico Korben,Buenos Aires,Argentina,1426[20]Fundacion Centro Oncológico Riojano Integral para la Investigación y Prevención del Cáncer,La Rioja,Argentina,F5300COE[21]Centro de Diagnostico Investigacion y Tratamiento,Salta,Argentina,4400[22]Campbelltown Hospital,Campbelltown,New South Wales,Australia,2560[23]Concord Repatriation General Hospital,Concord,New South Wales,Australia,2139[24]Nepean Cancer Centre,Kingswood,New South Wales,Australia,2747[25]GenesisCare -North Shore Oncology,St Leonards,New South Wales,Australia,2065[26]Calvary Mater Newcastle Hospital,Waratah,New South Wales,Australia,2298[27]Toowoomba Hospital,Toowoomba,Queensland,Australia,4350[28]Princess Alexandra Hospital,Woolloongabba,Queensland,Australia,4102[29]Cancer Research South Australia,Adelaide,South Australia,Australia,5000[30]Peter MacCallum Cancer Centre,Melbourne,Victoria,Australia,3000[31]The Alfred Hospital,Melbourne,Victoria,Australia,3004[32]Medizinische Universitaet Graz,Graz,Austria,8036[33]Klinikum Klagenfurt am Woerthersee,Klagenfurt,Austria,9020[34]Universitaetsklinikum Krems,Krems,Austria,3500[35]Landeskrankenhaus Salzburg,Salzburg,Austria,5020[36]Klinikum Wels - Grieskirchen GmbH,Wels,Austria,4600[37]Chirec - Delta Ziekenhuis,Auderghem,Belgium,1160[38]Algemeen Ziekenhuis Maria Middelares,Gent,Belgium,9000[39]Universitair Ziekenhuis Leuven - Campus Gasthuisberg,Leuven,Belgium,3000[40]Centre Hospitalier Regional de la Citadelle,Liège,Belgium,4000[41]Algemeen Ziekenhuis Sint-Maarten,Mechelen,Belgium,2800[42]Hospital Sirio Libanes,Brasilia,Distrito Federal,Brazil,70200-730[43]Hospital Evangelico de Cachoeiro de Itapemirim,Cachoeiro de Itapemirim,Espírito Santo,Brazil,29308-014[44]Nucleo de Ensino Pesquisa e Inovacao Mario Penna,Belo Horizonte,Minas Gerais,Brazil,30380-472[45]Centro de Tratamento Oncologico - Cto,Belem,Pará,Brazil,66053-000[46]Instituto de Medicina Integral Professor Fernando Figueira - Imip,Recife,Pernambuco,Brazil,50070-550[47]Irmandade da Santa Casa de Misericordia de Porto Alegre,Porto Alegre,Rio Grande Do Sul,Brazil,90050-170[48]Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul,Porto Alegre,Rio Grande Do Sul,Brazil,90610-000[49]Centro de pesquisa em oncologia Hospital Ana Nery,Santa Cruz do Sul,Rio Grande Do Sul,Brazil,96835-090[50]Clinica de Neoplasias Litoral,Itajai,Santa Catarina,Brazil,88301-220[51]Fundacao Pio 12 Hospital de Amor de Barretos,Barretos,São Paulo,Brazil,14784-400[52]Santa Casa de Misericordia de Santos - Iscms,Santos,São Paulo,Brazil,11075-900[53]Hospital de Base de Sao Jose do Rio Preto,Sao Jose do Rio Preto,São Paulo,Brazil,15090-000[54]Beneficencia Portuguesa de Sao Paulo - Bp,Sao Paulo,São Paulo,Brazil,01323-900[55]Fundacao Antonio Prudente,Sao Paulo,São Paulo,Brazil,01509-900[56]Oncoclinicas Rio de Janeiro S A,Rio de Janeiro,Brazil,22250-905[57]Instituto de Ensino e Pesquisa Sao Lucas Iep Sao Lucas,São Paulo,Brazil,01236-030[58]Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira Icesp,São Paulo,Brazil,01246-000[59]Multiprofile Hospital for Active Treatment - Uni Hospital OOD,Panagyurishte,Bulgaria,4500[60]University Multiprofile Hospital for Active Treatment Sveta Marina - Pleven OOD,Pleven,Bulgaria,5800[61]Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD,Sofia,Bulgaria,1407[62]University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD,Sofia,Bulgaria,1527[63]Queen Elizabeth II, Health Sciences Centre,Halifax,Nova Scotia,Canada,B3H 1V7[64]Sunnybrook Research Institute Sunnybrook Health Sciences Centre,Toronto,Ontario,Canada,M4N 3M5[65]McGill University Health Centre Glen Site,Montreal,Quebec,Canada,H4A 3J1[66]CIUSSS - du Nord-de-lIle-de-Montreal / Hopital Sacre-Coeur de Montreal,Montreal,Quebec,Canada,H4J 1C5[67]Institut Universitaire de cardiologie et de pneumologie de Quebec,Quebec City,Quebec,Canada,G1V 4G5[68]Allan Blair Cancer Centre,Regina,Saskatchewan,Canada,S4T 7T1[69]Saskatoon Cancer Centre,Saskatoon,Saskatchewan,Canada,S7N 4H4[70]James Lind Centro de Investigacion del Cancer,Temuco,Cautín,Chile,4800827[71]Clinica CIDO,Temuco,Cautín,Chile,4810218[72]Orlandi Oncologia,Santiago,Chile,7500713[73]Fundacion Arturo Lopez Perez,Santiago,Chile,7500836[74]Biocinetic,Santiago,Chile,8330336[75]Centro de Investigacion del Maule,Talca,Chile,346000[76]The First Affiliated Hospital of Bengbu Medical University,Bengbu,Anhui,China,233004[77]Anhui Chest Hospital,Hefei,Anhui,China,230022[78]Fujian Medical University Union Hospital,Fuzhou,Fujian,China,350109[79]The First Affiliated Hospital of Xiamen University,Xiamen,Fujian,China,361003[80]Zhongshan Hospital Xiamen University,Xiamen,Fujian,China,361004[81]Gansu Province Cancer Hospital,Lanzhou,Gansu,China,730050[82]Guangdong Provincial Peoples Hospital,Guangzhou,Guangdong,China,510080[83]Affiliated Cancer Hospital and institute of Guangzhou Medical University,Guangzhou,Guangdong,China,510095[84]Cancer Hospital of Shantou University Medical College,Shantou,Guangdong,China,515031[85]Liuzhou Peoples Hospital,Liuzhou,Guangxi,China,545006[86]Guangxi Medical University Cancer Hospital,Nanning,Guangxi,China,530021[87]Hainan Cancer Hospital,Haikou,Hainan,China,570311[88]Affiliated Hospital of Hebei University,Baoding,Hebei,China,071000[89]AnYang Tumor Hospital,Anyang,Henan,China,455001
The primary objective of this study is to compare progression-free survival (PFS) in participants who receive sotorasib with platinum doublet chemotherapy versus participants who receive pembrolizumab with platinum doublet chemotherapy.
