研究单位：[1]Eli Lilly and Company[2]Centro Medico Privado CEMAIC,Capital,Córdoba,Argentina,X5008HHW[3]Instituto Médico Río Cuarto,Río Cuarto,Córdoba,Argentina,5800[4]Clinica Viedma,Viedma,Río Negro,Argentina,R8500ACE[5]Centro Medico San Roque,San Miguel de Tucumán,Tucumán,Argentina,T4000IAK[6]Centro Oncologico Korben,Buenos Aires,Argentina,1426[7]Fundación Respirar,Buenos Aires,Argentina,C1426ABP[8]Fundación CORI para la Investigación y Prevención del Cáncer,La Rioja,Argentina,F5300COE[9]Fundacion Scherbovsky,Mendoza,Argentina,5500[10]CER San Juan,San Juan,Argentina,5400[11]Instituto San Marcos,San Juan,Argentina,5400[12]Coffs Harbour Health Campus,Coffs Harbour,New South Wales,Australia,2450[13]St Vincent's Hospital,Darlinghurst,New South Wales,Australia,2010[14]Gosford Hospital,Gosford,New South Wales,Australia,2250[15]Liverpool Hospital,Liverpool,New South Wales,Australia,2170[16]Lake Macquarie Private Hospital,Newcastle,New South Wales,Australia,2290[17]Mater Hospital Sydney,Sydney,New South Wales,Australia,2060[18]Royal Darwin Hospital,Tiwi,Northern Territory,Australia,0810[19]Gold Coast University Hospital,Southport,Queensland,Australia,4215[20]Hervey Bay Hospital,Urraween,Queensland,Australia,4655[21]The Queen Elizabeth Hospital,Woodville,South Australia,Australia,5011[22]Launceston General Hospital,Launceston,Tasmania,Australia,7250[23]Ballarat Health Services,Ballarat Central,Victoria,Australia,3350[24]Box Hill Hospital,Box Hill,Victoria,Australia,3128[25]Monash Health,Clayton,Victoria,Australia,3168[26]Barwon Health,Geelong,Victoria,Australia,3220[27]Northern Hospital,Melbourne,Victoria,Australia,3076[28]Maroondah Hospital,Melbourne,Victoria,Australia,3135[29]Goulburn Valley Health,Shepparton,Victoria,Australia,3630[30]Breast Cancer Research Centre-WA,Nedlands,Western Australia,Australia,6009[31]Private Practice - Dr. Hubalek,Schwaz,Tirol,Austria,6130[32]Franziskus Spital GmbH,Vienna,Wien,Austria,1050[33]Uniklinikum Salzburg, Universitaetsklinik für Innere Medizin III der PMU,Salzburg,Austria,5020[34]CHIREC - site delta,Auderghem,Bruxelles-Capitale, Région De,Belgium,1160[35]Cliniques universitaires Saint-Luc,Brussels,Bruxelles-Capitale, Région De,Belgium,1200[36]Institut Jules Bordet,Anderlecht,Bruxelles-,Belgium,1070[37]Groupe Jolimont,La Louvière,Hainaut,Belgium,7100[38]CHU de Charleroi - Hopital Civil Marie Curie,Lodelinsart,Hainaut,Belgium,6042[39]Jessa Ziekenhuis,Hasselt,Limburg,Belgium,3500[40]Jan Yperman ziekenhuis,Ieper,West-Vlaanderen,Belgium,8900[41]AZ Groeninge Campus Kennedylaan,Kortrijk,West-Vlaanderen,Belgium,8500[42]CHU UCL Namur/Site Sainte Elisabeth,Namur,Belgium,5000[43]Clinique Saint Pierre,Ottignies,Belgium,1340[44]CHR Verviers - La Tourelle,Verviers,Belgium,4800[45]Nucleo de Oncologia da Bahia,Salvador,Bahia,Brazil,40170-110[46]Centro de Pesquisa Clínica do Instituto do Câncer do Ceará,Fortaleza,Ceará,Brazil,60430235[47]CEDOES,Vitória,Espírito Santo,Brazil,29055450[48]Hospital Araújo Jorge,Goiânia,Goiás,Brazil,74605070[49]Oncocentro de Minas Gerais,Belo Horizonte,Minas Gera,Brazil,30180-060[50]Centro Integrado de Oncologia de Curitiba,Curitiba,Paraná,Brazil,80810050[51]Hospital de Cancer de Londrina,Londrina,Paraná,Brazil,86015-520[52]CTO - Centro de Tratamento Oncológico,Belem,Pará,Brazil,66063-495[53]Multihemo,Recife,Pernambuco,Brazil,50070-170[54]ONCOSITE - Centro de Pesquisa Clinica em Oncologia,Ijui,Rio Grande Do Sul,Brazil,98700-000[55]Centro Gaucho Integrado De Oncologia, Hematologia, Ensino E Pesquisa,Porto Alegre,Rio Grande Do Sul,Brazil,90110-270[56]Hospital Moinhos de Vento,Porto Alegre,Rio Grande,Brazil,90035001[57]Hospital de Amor Amazônia,Porto Velho,Rondônia,Brazil,76834-899[58]Fundação Pio XII - Hospital de Câncer de Barretos,Barretos,São Paulo,Brazil,14784400[59]Hospital de Clínicas de Ribeirão Preto,Ribeirão Preto,São Paulo,Brazil,14051-140[60]Faculdade de Medicina do ABC,Santo André,São Paulo,Brazil,09060-650[61]Hospital Sírio Libanês,Sao Paulo,São Paulo,Brazil,01308-060[62]Hospital BP,Sao Paulo,São Paulo,Brazil,01321-001[63]A. C. Camargo Cancer Center,Sao Paulo,São Paulo,Brazil,01509-010[64]Instituto D'Or de Pesquisa e Ensino (IDOR),Sao Paulo,São Paulo,Brazil,04543-000[65]Hospital de Base de São José do Rio Preto,São José do Rio Preto,São Paulo,Brazil,15091-000[66]Hospital Sirio Libanes,Brasilia,Brazil,70200-730[67]Hospital São Lucas da PUCRS,Porto Alegre,Brazil,90610[68]Instituto Nacional de Câncer - INCA,Rio de Janeiro,Brazil,20560121[69]Hospital São Lucas de Copacabana,Rio de Janeiro,Brazil,22061-080[70]Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA,Rio de Janeiro,Brazil,22250-905[71]Instituto de Educação, Pesquisa e Gestão em Saúde,Rio de Janeiro,Brazil,22793-080[72]IPITEC,São Paulo,Brazil,01223-001[73]NotreDame Intermedica Saude S.A,São Paulo,Brazil,01229-010[74]Instituto de Ensino e Pesquisa São Lucas,São Paulo,Brazil,01236030[75]Icesp - Instituto Do Câncer Do Estado de São Paulo,São Paulo,Brazil,01246-000[76]Clínica de Pesquisa e Centro de Estudos em Ginecologia Oncológica e Mamária LTDA,São Paulo,Brazil,01317-000[77]Hospital Alemao Oswaldo Cruz,São Paulo,Brazil,01327-001[78]Núcleo de Pesquisa Clínica da Rede São Camilo,São Paulo,Brazil,04014-002[79]Instituto de Assist├ncia M├dica ao Servidor P,São Paulo,Brazil,04039-901[80]Tom Baker Cancer Center,Calgary,Alberta,Canada,T2N 4N2[81]BC Cancer Surrey,Surrey,British Columbia,Canada,V3V 1Z2[82]London Regional Cancer Program,London,Ontario,Canada,N6A 5W9[83]Humber River Hospital,Toronto,Ontario,Canada,M3M 0B2[84]Sunnybrook Research Institute - Odette Cancer Centre,Toronto,Ontario,Canada,M4N 3M5[85]Jewish General Hospital,Montreal,Quebec,Canada,H3T 1E2[86]Hopital du Sacre-Coeur de Montreal,Montreal,Quebec,Canada,H4J 1C5[87]Centre Hospitalier de l'Université de Montréal,Montréal,Quebec,Canada,H2X 3E4[88]Hopital Du Saint-Sacrement,Quebec City,Quebec,Canada,G1S 4L8[89]Wannan Medical College Yijishan Hospital,Wuhu Shi,Anhui,China,241001[90]Cancer Hospital Chinese Academy of Medical Science,Beijing,Beijing,China,100021[91]Peking University People's Hospital,Beijing,Beijing,China,100034[92]Beijing Friendship Hospital,Beijing,Beijing,China,100050[93]Fujian Medical University Union Hospital-1 Bingfanglou,Fuzhou,Fujian,China,350001[94]Sun Yat-Sen University Cancer Centre,Guangzhou,Guangdong,China,510060[95]Guangdong Maternity and Child Health Care Hospital,Guangzhou,Guangdong,China,511400[96]Huizhou Municipal Central Hospital,Huizhou,Guangdong,China,516001[97]Huizhou Municipal Central Hospital,Huizhou,Guangdong,China,516001[98]Jiangmen Center Hospital,Jiangmen,Guangdong,China,529000[99]ShenZhen People's Hospital,Shenzhen,Guangdong,China,518020[100]Hainan General Hospital,Haikou,Hainan,China,570311[101]Affiliated Hospital of Hebei University,Baoding,Hebei,China,71066
研究目的：
The main purpose of this study is to measure how well imlunestrant works compared to standard hormone therapy in participants with early breast cancer that is estrogen receptor positive (ER+) and human epidermal receptor 2 negative (HER2-). Participants must have already taken endocrine therapy for two to five years and must have a higher-than-average risk for their cancer to return. Study participation could last up to 10 years.
