研究单位：[1]AbbVie[2]University of South Alabama /ID# 212939,Mobile,Alabama,United States,36604-3302[3]Mayo Clinic Arizona /ID# 218550,Phoenix,Arizona,United States,85054-4504[4]Highlands Oncology Group, PA /ID# 215600,Springdale,Arkansas,United States,72762[5]University of California, Los Angeles /ID# 203219,Los Angeles,California,United States,90095[6]LA Hematology-Oncology Med Group /ID# 203338,Orange,California,United States,92868[7]Sutter Medical Center Sacramen /ID# 203299,Sacramento,California,United States,95816[8]Icri /Id# 227835,Whittier,California,United States,90603[9]Univ of Colorado Cancer Center /ID# 203212,Aurora,Colorado,United States,80045[10]Rocky Mountain Cancer Centers /ID# 215789,Lone Tree,Colorado,United States,80124[11]Advanced Cancer Treatment Center /ID# 239565,Brooksville,Florida,United States,34613-6072[12]AdventHealth Celebration /ID# 215649,Celebration,Florida,United States,34747-4970[13]Mayo Clinic /ID# 218488,Jacksonville,Florida,United States,32224[14]AdventHealth Cancer Institute - Orlando /ID# 239960,Orlando,Florida,United States,32804[15]Straub Clinic and Hospital /ID# 217905,Honolulu,Hawaii,United States,96813-3097[16]Northwestern University Feinberg School of Medicine /ID# 203239,Chicago,Illinois,United States,60611-2927[17]The University of Chicago Medical Center /ID# 203216,Chicago,Illinois,United States,60637-1443[18]NorthShore University HealthSystem /ID# 215583,Evanston,Illinois,United States,60201[19]Ingalls Memorial Hosp /ID# 203228,Harvey,Illinois,United States,60426[20]Joliet Oncology-Hematology Associates, LTD /ID# 203238,Joliet,Illinois,United States,60435[21]Goshen Center for Cancer Care /ID# 215584,Goshen,Indiana,United States,46526[22]Univ Kansas Med Ctr /ID# 216804,Kansas City,Kansas,United States,66160[23]Cancer Center of Kansas /ID# 203235,Wichita,Kansas,United States,67214[24]Baptist Health /ID# 203283,Lexington,Kentucky,United States,40503-1463[25]Norton Cancer Institute - St Matthews /ID# 203284,Louisville,Kentucky,United States,40207[26]Central Maine Medical Center /ID# 216583,Lewiston,Maine,United States,04240[27]Massachusetts General Hospital /ID# 203215,Boston,Massachusetts,United States,02114[28]Beth Israel Deaconess Medical Center /ID# 208124,Boston,Massachusetts,United States,02215-5400[29]Dana-Farber Cancer Institute /ID# 203248,Boston,Massachusetts,United States,02215[30]Henry Ford Hospital - West Bloomfield /ID# 203220,West Bloomfield,Michigan,United States,48322[31]Mayo Clinic - Rochester /ID# 215603,Rochester,Minnesota,United States,55905-0001[32]Hattiesburg Clinic /ID# 227691,Hattiesburg,Mississippi,United States,39401[33]St. Lukes Cancer Institute /ID# 227697,Kansas City,Missouri,United States,64111-5905[34]Washington University-School of Medicine /ID# 203217,Saint Louis,Missouri,United States,63110[35]St. Vincent Frontier Cancer Center /ID# 203292,Billings,Montana,United States,59102[36]Dartmouth-Hitchcock Medical Center /ID# 203350,Lebanon,New Hampshire,United States,03756[37]Titan Health Partners LLC, d/b/a Astera Cancer Care /ID# 228868,East Brunswick,New Jersey,United States,08816[38]Atlantic Health System /ID# 203404,Morristown,New Jersey,United States,07960-6136[39]Capital Health Medical Center /ID# 203403,Pennington,New Jersey,United States,08534-2520[40]Overlook Medical Center /ID# 211160,Summit,New Jersey,United States,07901-3533[41]University of New Mexico /ID# 208339,Albuquerque,New Mexico,United States,87102-4517[42]Gabrail Cancer Center Research /ID# 216056,Canton,Ohio,United States,44718[43]Univ Hosp Cleveland /ID# 215648,Cleveland,Ohio,United States,44106[44]Mercy Cancer Center /ID# 231972,Elyria,Ohio,United States,44024[45]Mercy Research Mercy Clinic Oklahoma Communities, Inc. / OKC OK /ID# 230154,Oklahoma City,Oklahoma,United States,73120
[48]Allegheny General Hospital /ID# 215585,Pittsburgh,Pennsylvania,United States,15212[46]Penn State University and Milton S. Hershey Medical Center /ID# 221844,Hershey,Pennsylvania,United States,17033-2360[47]Veterans Healthcare System /ID# 215602,Pittsburgh,Pennsylvania,United States,15240[48]Thompson Cancer Survival Ctr /ID# 228874,Knoxville,Tennessee,United States,37916[49]Vanderbilt Ingram Cancer Center /ID# 203281,Nashville,Tennessee,United States,37232-0021[50]Houston Methodist Hospital - Scurlock Tower /ID# 213268,Houston,Texas,United States,77030[51]Baylor Scott & White Medical Center- Temple /ID# 216578,Temple,Texas,United States,76508-0001[52]Virginia Cancer Specialists - Fairfax /ID# 203224,Fairfax,Virginia,United States,22031[53]Valley Medical Center /ID# 231459,Renton,Washington,United States,98055-5738[54]University of Washington /ID# 206056,Seattle,Washington,United States,98109[55]Medical College of Wisconsin /ID# 210062,Milwaukee,Wisconsin,United States,53226-3522[56]The Kinghorn Cancer Centre /ID# 207666,Darlinghurst,New South Wales,Australia,2010[57]Newcastle Private Hospital /ID# 206600,Lambton Heights,New South Wales,Australia,2305[58]The Tweed Hospital /ID# 206601,Tweed Heads,New South Wales,Australia,2485[59]Mater Misericordiae Limited /ID# 229639,South Brisbane,Queensland,Australia,4101[60]St John Of God Subiaco Hospital /ID# 226943,Subiaco,Western Australia,Australia,6008[61]Universitair Ziekenhuis Antwerpen /ID# 217430,Edegem,Antwerpen,Belgium,2650[62]Institut Jules Bordet /ID# 238614,Anderlecht,Belgium,1070[63]AZ Maria Middelares /ID# 233474,Gent,Belgium,9000[64]Jessa Ziekenhuis /ID# 234047,Hasselt,Belgium,3500[65]AZ Groeninge /ID# 217431,Kortrijk,Belgium,8500[66]Pôle Hospitalier Jolimont /ID# 230586,La Louvière,Belgium,7100[67]CHU de Liege /ID# 230589,Liege,Belgium,4000[68]CHU UCL Namur - Sainte Elisabeth /ID# 234048,Namur,Belgium,5000[69]Vitaz /Id# 239966,Sint-Niklaas,Belgium,9100[70]MHAT Dobrich /ID# 230074,Dobrich,Bulgaria,9300[71]UMHAT Dr Georgi Stranski EAD /ID# 232024,Pleven,Bulgaria,5800[72]Medical Center Nadezhda /ID# 230473,Sofia,Bulgaria,1330[73]Acibadem City Clinic Tokuda University Hospital EAD /ID# 232010,Sofia,Bulgaria,1407[74]Cross Cancer Institute /ID# 204540,Edmonton,Alberta,Canada,T6G 1Z2[75]Ottawa Hospital Research Institute /ID# 205579,Ottawa,Ontario,Canada,K1H 8L6[76]Princess Margaret Cancer Centre /ID# 204423,Toronto,Ontario,Canada,M5G 2M9[77]CISSS de la Monteregie /ID# 211356,Greenfield Park,Quebec,Canada,J4V 2H1[78]Anhui Provincial Hospital /ID# 212096,Hefei,Anhui,China,230001[79]Anhui Chest Hospital /ID# 239048,Hefei,Anhui,China,230022[80]Anhui Provincial Cancer Hospital /ID# 239058,Hefei,Anhui,China,230031[81]Beijing Cancer Hospital /ID# 210133,Beijing,Beijing,China,100142[82]Fujian Provincial Cancer Hospital /ID# 210808,Fuzhou,Fujian,China,350014[83]The First Affiliated Hospital of Guangzhou Medical University /ID# 232261,Guangzhou,Guangdong,China,510163[84]Guangxi Medical University Cancer Center /ID# 231560,Nanning,Guangxi,China,530027[85]Affiliated Hospital of Hebei University /ID# 227262,Baoding,Hebei,China,071000[86]Harbin Medical University Cancer Hospital /ID# 231573,Harbin,Heilongjiang,China,150081[87]Henan Cancer Hospital /ID# 210961,Zhengzhou,Henan,China,450008[88]Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 211119,Wuhan,Hubei,China,430022[89]The First People's Hospital of Changzhou /ID# 210787,Changzhou,Jiangsu,China,213003[90]Jilin Cancer Hospital /ID# 210563,Changchun,Jilin,China,130012[91]Shandong Cancer Hospital /ID# 231577,Jinan,Shandong,China,251601
This study is designed to identify the target Non-Small Cell Lung Cancer (NSCLC) population(s) that overexpress c-Met (c-Met+) best suited for telisotuzumab vedotin therapy in the second line or third line setting (Stage 1) and then to expand the group(s) to further evaluate efficacy in the selected population(s) (Stage 2). After the Stage 2 global enrollment is completed, an additional cohort at an alternate dose level will evaluate the safety and efficacy of telisotuzumab vedotin (Stage 3).
