个人科研网厅 | | 帮助
高级检索
当前位置： 首页 > 详情页

Pro-inflammatory and proliferative microglia drive progression of glioblastoma.

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Hailong Liu[1,2] * ; Youliang Sun[4] * ; Qian Zhang[5,6] * ; Wei Jin[7] * ; Renata E. Gordon[8] ; Yanyang Zhang[1] ; Jian Wang[1] ; Caihong Sun[1] ; Zeyuan John Wang[9] ; Xueling Qi[10] ; Junping Zhang[11] ; Boyuan Huang[12] ; Qiuping Gui[7] ; Hongyu Yuan[13] ; Ling Chen[1] ; Xiaodong Ma[1] ; Chuan Fang[14] ; Yong-qiang Liu[3] ; Xinguang Yu[1] ; Shiyu Feng[1] ;
机构： [1]Department of Neurosurgery, The First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, P.R. China [2]Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 10070, P.R. China [3]Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, Guangzhou University of Chinese Medicine, Guangzhou 510006, P.R. China [4]School of Basic Medical Science, Capital Medical University, Beijing 100069, P.R. China [5]Medical Laboratory Center, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, P.R. China [6]Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen 518000, P.R. China [7]Department of Pathology, The First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, P.R. China [8]Langhorne, Bucks County, PA 19047, US [9]School of Pharmaceutical Sciences, Temple University, Philadelphia, PA 19140, USA [10]Department of Neuro-Pathology, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, P. R. China [11]Department of Neuro-Oncology, Sanbo Brain Hospital, Capital Medical University, Beijing 100093, P.R. China [12]Department of Neurosurgery, Beijing Electric Power Hospital, Beijing 100073, P.R. China [13]State Key Laboratory of Molecular Oncology, Chinese Academy of Medical Science Cancer Hospital/National Cancer Center, Beijing 100021, P.R. China [14]Department of Neurosurgery,The Affiliated Hospital of Hebei University,Baoding 122311,P.R. China
出处：
DOI： 10.1016/j.celrep.2021.109718
ISSN：

摘要：
Scant understanding of the glioblastoma microenvironment and molecular bases hampers development of efficient treatment strategies. Analyses of gene signatures of human gliomas demonstrate that the SETD2 mutation is correlated with poor prognosis of IDH1/2 wild-type (IDH-WT) adult glioblastoma patients. To better understand the crosstalk between SETD2 mutant (SETD2-mut) glioblastoma cells and the tumor microenvironment, we leverage single-cell transcriptomics to comprehensively map cellular populations in glioblastoma. In this study, we identify a specific subtype of high-grade glioma-associated microglia (HGG-AM). Further analysis shows that transforming growth factor (TGF)-β1 derived from SETD2-mut/IDH-WT tumor cells activates HGG-AM, exhibiting pro-inflammation and proliferation signatures. Particularly, HGG-AM secretes interleukin (IL)-1β via the apolipoprotein E (ApoE)-mediated NLRP1 inflammasome, thereby promoting tumor progression. HGG-AM present extensive proliferation and infiltration to supplement the activated microglia pool. Notably, TGF-β1/TβRI depletion dramatically reduces HGG-AM density and suppresses tumor growth. Altogether, our studies identify a specific microglia subpopulation and establish the cellular basis of interactions between HGG-AM and glioblastoma cells.Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

基金：
National Natural Science Foundation of China (81902975 to H.L. and 81871087 and 1716312-zt-00600303 to X.Y.), the National Key Research and Development Program of China (2018YFC1002500 to X.Y.), the 65th China Postdoctoral Science Foundation (2019M653940 to H.L.), the Medical Big Data Research Program of Chinese PLA General Hospital (2018MBD-20 to S.F.), and by the Clinical Research Support Program of Chinese PLA General Hospital (2016FCCXYY2010 to S.F.).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
最新[2025]版：
大类 | 1 区 生物学
小类 | 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Neurosurgery, The First Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100853, P.R. China [2]Department of Radiotherapy, Beijing Tiantan Hospital, Capital Medical University, Beijing 10070, P.R. China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Hailong Liu,Youliang Sun,Qian Zhang,et al.Pro-inflammatory and proliferative microglia drive progression of glioblastoma.[J].CELL REPORTS.2021,36(11):109718.doi:10.1016/j.celrep.2021.109718.
APA：
Hailong Liu,Youliang Sun,Qian Zhang,Wei Jin,Renata E. Gordon...&Shiyu Feng.(2021).Pro-inflammatory and proliferative microglia drive progression of glioblastoma..CELL REPORTS,36,(11)
MLA：
Hailong Liu,et al."Pro-inflammatory and proliferative microglia drive progression of glioblastoma.".CELL REPORTS 36..11(2021):109718

资源点击量：15101 今日访问量：2 总访问量：962 更新日期：2025-05-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 河北大学附属医院 技术支持：重庆聚合科技有限公司 地址：保定市莲池区裕华东路212号