机构：[1]Division of Head and Neck Cancer, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.四川大学华西医院[2]Department of Radiation Oncology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.河北大学附属医院[3]Division of Thoracic Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.四川大学华西医院
Hepatitis B virus (HBV) reactivation during chemotherapy is a major concern and is widely reported, particularly in association with hematological malignancies and lymphomas. While lung cancer ranks first in incidence and mortality worldwide, HBV reactivation has been largely overlooked in this disease. As regards small-cell lung cancer (SCLC), HBV reactivation has rarely been reported. We herein report the case of a hepatitis B surface antigen-seropositive SCLC patient in whom HBV was reactivated during the course of chemotherapy, despite preemptive use of lamivudine. The patient developed fulminant viral hepatitis and succumbed to liver failure. The aim of this report was to highlight the major but overlooked issue of HBV reactivation in SCLC, and suggest that agents more potent than lamivudine may be more efficacious in high-risk patients.
基金：
The present study was supported by the Natural Science Foundation of China (grant no. 81272684).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
无
最新[2025]版：
大类|4 区医学
小类|4 区肿瘤学
第一作者：
第一作者机构：[1]Division of Head and Neck Cancer, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.
通讯作者：
通讯机构：[3]Division of Thoracic Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.[*1]Division of Thoracic Oncology, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 37 GuoXue Lane, Chengdu, Sichuan 610041, P.R. China
推荐引用方式(GB/T 7714)：
Qin Lei,Wang Fang,Zou Bing-Wen,et al.Chemotherapy-induced fatal hepatitis B virus reactivation in a small-cell lung cancer patient[J].Molecular And Clinical Oncology.2016,5(4):382-384.doi:10.3892/mco.2016.989.
APA：
Qin Lei,Wang Fang,Zou Bing-Wen&Ding Zhen-Yu.(2016).Chemotherapy-induced fatal hepatitis B virus reactivation in a small-cell lung cancer patient.Molecular And Clinical Oncology,5,(4)
MLA：
Qin Lei,et al."Chemotherapy-induced fatal hepatitis B virus reactivation in a small-cell lung cancer patient".Molecular And Clinical Oncology 5..4(2016):382-384
